Heliotropiumides A and B, new phenolamides with N-carbamoyl putrescine moiety from Heliotropium foertherianum collected in Hawaii and their biological activities

Cai, You-Sheng; Sarotti, Ariel Marcelo; Gündisch, Daniela; Kondratyuk, Tamara P.; Pezzuto, John; Turkson, James; Cao, Shugeng

Heliotropiumides A and B, new phenolamides with N-carbamoyl putrescine moiety from Heliotropium foertherianum collected in Hawaii and their biological activities Volver a la Vista simple
dc.conicet.fuente	individual
dc.conicet.organizacion	University of Hawaii at Hilo
dc.conicet.organizacion	Wuhan University
dc.conicet.organizacion	Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario
dc.conicet.organizacion	University of Hawaii at Hilo
dc.conicet.organizacion	University of Hawaii at Hilo
dc.conicet.organizacion	Long Island University
dc.conicet.organizacion	University of Hawaii Cancer Center
dc.conicet.organizacion	University of Hawaii Cancer Center
dc.conicet.organizacion	University of Hawaii at Hilo
dc.conicet.paisOrganizacion	Estados Unidos
dc.conicet.paisOrganizacion	China
dc.conicet.paisOrganizacion	Argentina
dc.conicet.paisOrganizacion	Estados Unidos
dc.conicet.paisOrganizacion	Estados Unidos
dc.conicet.paisOrganizacion	Estados Unidos
dc.conicet.paisOrganizacion	Estados Unidos
dc.conicet.paisOrganizacion	Estados Unidos
dc.conicet.paisOrganizacion	Estados Unidos
dc.conicet.produccionid	6892880
dc.contributor.author	Cai, You-Sheng
dc.contributor.author	Sarotti, Ariel Marcelo
dc.contributor.author	Gündisch, Daniela
dc.contributor.author	Kondratyuk, Tamara P.
dc.contributor.author	Pezzuto, John
dc.contributor.author	Turkson, James
dc.contributor.author	Cao, Shugeng
dc.date.accessioned	2018-07-26T18:46:06Z
dc.date.available	2018-07-26T18:46:06Z
dc.date.issued	2017-09
dc.date.updated	2018-07-26T14:01:21Z
dc.description.abstract	Two new compounds heliotropiumides A (1) and B (2), phenolamides each with an uncommon carbamoyl putrescine moiety, were isolated from the seeds of a naturalized Hawaiian higher plant, Heliotropium foertherianum Diane & Hilger in the borage family, which is widely used for the treatment of ciguatera fish poisoning. The structures of compounds 1 and 2 were characterized based on MS spectroscopic and NMR analysis, and DP4+ calculations. The absolute configuration (AC) of compound 1 was determined by comparison of its optical rotation with those reported in literature. Compound 2 showed inhibition against NF-κB with an IC50 value of 36 μM.	es
dc.description.fil	Fil: Cai, You-Sheng. University of Hawaii at Hilo; Estados Unidos. Wuhan University; China
dc.description.fil	Fil: Sarotti, Ariel Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina
dc.description.fil	Fil: Gündisch, Daniela. University of Hawaii at Hilo; Estados Unidos
dc.description.fil	Fil: Kondratyuk, Tamara P.. University of Hawaii at Hilo; Estados Unidos
dc.description.fil	Fil: Pezzuto, John. Long Island University; Estados Unidos. University of Hawaii Cancer Center; Estados Unidos
dc.description.fil	Fil: Turkson, James. University of Hawaii Cancer Center; Estados Unidos
dc.description.fil	Fil: Cao, Shugeng. University of Hawaii at Hilo; Estados Unidos
dc.format	application/pdf	es
dc.identifier.citation	Cai, You-Sheng; Sarotti, Ariel Marcelo; Gündisch, Daniela; Kondratyuk, Tamara P.; Pezzuto, John; et al.; Heliotropiumides A and B, new phenolamides with N-carbamoyl putrescine moiety from Heliotropium foertherianum collected in Hawaii and their biological activities; Pergamon-Elsevier Science Ltd; Biorganic and Medicinal Chemistry Letters; 27; 20; 9-2017; 4630-4634	es
dc.identifier.institucional	CONICET
dc.identifier.issn	0960-894X	es
dc.identifier.repo	CONICET Digital
dc.identifier.uri	http://hdl.handle.net/11336/53189
dc.journal.ciudad	Hawai	es
dc.journal.number	20	es
dc.journal.pagination	4630-4634	es
dc.journal.pais	Estados Unidos	es
dc.journal.title	Biorganic and Medicinal Chemistry Letters	es
dc.journal.volume	27	es
dc.language.iso	eng	es
dc.publisher	Pergamon-Elsevier Science Ltd	es
dc.relation.alternativeid	info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1016/j.bmcl.2017.09.021
dc.relation.alternativeid	info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0960894X17309162
dc.rights	info:eu-repo/semantics/openAccess	*
dc.rights.uri	https://creativecommons.org/licenses/by-nc-sa/2.5/ar/	*
dc.subject	Heliotropium Foertherianum	es
dc.subject	Heliotropiumides	es
dc.subject	Nf-ΚB	es
dc.subject	Nmr Dp4+ Calculation	es
dc.subject	Optical Rotation	es
dc.subject.classification	Otras Ciencias Químicas	es
dc.subject.classification	Ciencias Químicas	es
dc.subject.classification	CIENCIAS NATURALES Y EXACTAS	es
dc.title	Heliotropiumides A and B, new phenolamides with N-carbamoyl putrescine moiety from Heliotropium foertherianum collected in Hawaii and their biological activities	es
dc.type	info:eu-repo/semantics/article
dc.type	info:ar-repo/semantics/artículo
dc.type	info:eu-repo/semantics/publishedVersion

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