Antiinflammatory actions of tibolone in the spinal cord of experimental autoimmune encephalomyelitis mice

Abstract

Tibolone (TIB) is a synthetic estrogenic compound with tissue-specific actions commonly used to prevent symptoms in postmeno-pausal women. The tissue selectivity of TIB depends on its specific local transformation to active metabolites that can exert estrogenic, progestinic and androgenic activities. Recently, antioxidant and anti-inflammatory actions of TIB have been described in the CNS.