A Review on the Use of Deep Eutectic Solvents in Protection Reactions

Abstract

Given the recent research on the application of eco-sustainable methods in organic chemistry,we have focused our attention on the derivatization processes for fundamental functional groups inorganic chemistry, such as amino, hydroxyl and carbonyl groups. Protection reactions are neededto temporarily block a certain reactive site on a molecule. The use of green solvents in this contexthas made an excellent contribution to the development of eco-sustainable methods. In recent years,deep eutectic solvents (DESs) have had great success as a new class of green solvents used in variouschemical applications, such as extraction or synthetic processes. These solvents are biodegradable andnontoxic. In this framework, a list of relevant works found in the literature is described, consideringDESs to be a good alternative to classic toxic solvents in the protection reactions of importantfunctional groups.