Rat ventral prostate microsomal biotransformation of ethanol to acetaldehyde and 1-hydroxyethyl radicals: Its potential contribution to prostate tumor promotion

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dc.conicet.fuenteunificacion
dc.conicet.organizacionConsejo Nacional de Investigaciones CientĆ­ficas y TĆ©cnicas. GP. CITEFA - Centro de Investigaciones ToxicolĆ³gicas (I)
dc.conicet.organizacionConsejo Nacional de Investigaciones CientĆ­ficas y TĆ©cnicas. GP. CITEFA - Centro de Investigaciones ToxicolĆ³gicas (I)
dc.conicet.organizacionConsejo Nacional de Investigaciones CientĆ­ficas y TĆ©cnicas. GP. CITEFA - Centro de Investigaciones ToxicolĆ³gicas (I)
dc.conicet.organizacionConsejo Nacional de Investigaciones CientĆ­ficas y TĆ©cnicas. GP. CITEFA - Centro de Investigaciones ToxicolĆ³gicas (I)
dc.conicet.paisOrganizacionArgentina
dc.conicet.paisOrganizacionArgentina
dc.conicet.paisOrganizacionArgentina
dc.conicet.paisOrganizacionArgentina
dc.conicet.produccionid6532858
dc.contributor.authorCastro, Gerardo Daniel
dc.contributor.authorDelgado De LayƱo, Aurora, M. A.
dc.contributor.authorCostantini, Martin Hernan
dc.contributor.authorCastro, Jose Alberto
dc.date.accessioned2019-09-02T19:24:25Z
dc.date.available2019-09-02T19:24:25Z
dc.date.issued2002-05
dc.date.updated2019-08-26T18:36:42Z
dc.description.abstractRat ventral prostate microsomal fraction was able to biotransform ethanol to acetaldehyde and 1-hydroxyethyl radicals (1HEt) in the presence of NADPH and oxygen. The enzymatic processes involved were not inhibited by desferrioxamine, CO, SKF 525A, 4-methylpyrazole, or polyclonal antibody against P450 reductase but they were significantly inhibited by diethyldithiocarbamate, 2-mercapto-1-methylimidazol, thiobenzamide, or diphenyleneiodonium chloride. Results would suggest the partial participation in these ethanol bioactivation processes of flavin containing monooxygenase (FMO) and/or other flavin dependent oxidases/ peroxidases and of a non-iron metal-containing enzymes. Acetaldehyde and free radicals production by prostate microsomal fraction might potentially contribute to tumor promotion in heavy alcohol drinkers.es
dc.description.filFil: Castro, Gerardo Daniel. Consejo Nacional de Investigaciones CientĆ­ficas y TĆ©cnicas. GP. CITEFA - Centro de Investigaciones ToxicolĆ³gicas (I); Argentina
dc.description.filFil: Delgado De LayƱo, Aurora, M. A.. Consejo Nacional de Investigaciones CientĆ­ficas y TĆ©cnicas. GP. CITEFA - Centro de Investigaciones ToxicolĆ³gicas (I); Argentina
dc.description.filFil: Costantini, Martin Hernan. Consejo Nacional de Investigaciones CientĆ­ficas y TĆ©cnicas. GP. CITEFA - Centro de Investigaciones ToxicolĆ³gicas (I); Argentina
dc.description.filFil: Castro, Jose Alberto. Consejo Nacional de Investigaciones CientĆ­ficas y TĆ©cnicas. GP. CITEFA - Centro de Investigaciones ToxicolĆ³gicas (I); Argentina
dc.formatapplication/pdfes
dc.identifier.citationCastro, Gerardo Daniel; Delgado De LayƱo, Aurora, M. A.; Costantini, Martin Hernan; Castro, Jose Alberto; Rat ventral prostate microsomal biotransformation of ethanol to acetaldehyde and 1-hydroxyethyl radicals: Its potential contribution to prostate tumor promotion; Wiley; Teratogenesis Carcinogenesis And Mutagenesis; 22; 5; 5-2002; 335-341es
dc.identifier.institucionalCONICET
dc.identifier.issn0270-3211es
dc.identifier.repoCONICET Digital
dc.identifier.urihttp://hdl.handle.net/11336/82751
dc.journal.ciudadHobokenes
dc.journal.number5es
dc.journal.pagination335-341es
dc.journal.paisEstados Unidoses
dc.journal.titleTeratogenesis Carcinogenesis And Mutagenesises
dc.journal.volume22es
dc.language.isoenges
dc.publisherWileyes
dc.relation.alternativeidinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/tcm.10028
dc.relation.alternativeidinfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/tcm.10028
dc.rightsinfo:eu-repo/semantics/openAccess*
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/*
dc.subjectAlcoholes
dc.subjectCanceres
dc.subjectFree Radicalses
dc.subjectGc-Mses
dc.subjectSpin Trappinges
dc.subject.classificationBioquĆ­mica y BiologĆ­a Moleculares
dc.subject.classificationCiencias BiolĆ³gicases
dc.subject.classificationCIENCIAS NATURALES Y EXACTASes
dc.titleRat ventral prostate microsomal biotransformation of ethanol to acetaldehyde and 1-hydroxyethyl radicals: Its potential contribution to prostate tumor promotiones
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artĆ­culo
dc.typeinfo:eu-repo/semantics/publishedVersion

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