CD95 (Fas) and CD95L (FasL)-mediated non-canonical signaling pathways

Abstract

Although the interaction of CD95L (also known as FasL) with its so-called death receptor CD95 (Fas) induces anapoptotic signal responsible for the elimination of infected and cancer cells and maintenance of tissue homeostasis,this receptor can also implement non apoptotic signaling pathways. This latter signaling is involved inmetastatic dissemination in certain cancers and the severity of auto-immune disorders. The signaling complexityof this pair is increased by the fact that CD95 expression itself seems to contribute to oncogenesis via a CD95Lindependentmanner and, that both ligand and receptor might interact with other partners modulating theirpathophysiological functions. Finally, CD95L itself can trigger cell signaling in immune cells rendering complexthe interpretation of mouse models in which CD95 or CD95L are knocked out. Herein, we discuss these noncanonicalresponses and their biological functions.