Comparative sequence analysis and adipose-specific expression of G0S2 and ATGL in sheep

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dc.conicet.fuenteindividual
dc.conicet.organizacionOhio University
dc.conicet.organizacionOhio University
dc.conicet.organizacionInner Mongolia University for Nationalities
dc.conicet.organizacionOhio University
dc.conicet.organizacionOhio University
dc.conicet.organizacionConsejo Nacional de Investigaciones Científicas y Técnicas
dc.conicet.organizacionOhio University
dc.conicet.organizacionConsejo Nacional de Investigaciones Científicas y Técnicas
dc.conicet.organizacionKyungpook National University
dc.conicet.organizacionOhio University
dc.conicet.organizacionSunchon National University
dc.conicet.organizacionOhio University
dc.conicet.paisOrganizacionEstados Unidos
dc.conicet.paisOrganizacionEstados Unidos
dc.conicet.paisOrganizacionChina
dc.conicet.paisOrganizacionEstados Unidos
dc.conicet.paisOrganizacionEstados Unidos
dc.conicet.paisOrganizacionArgentina
dc.conicet.paisOrganizacionEstados Unidos
dc.conicet.paisOrganizacionArgentina
dc.conicet.paisOrganizacionCorea del Sur
dc.conicet.paisOrganizacionEstados Unidos
dc.conicet.paisOrganizacionCorea del Sur
dc.conicet.paisOrganizacionEstados Unidos
dc.conicet.produccionid6668537
dc.contributor.authorAhn, Jinsoo
dc.contributor.authorWu, Huiguang
dc.contributor.authorSuh, Yeunsu
dc.contributor.authorCarranza Martin, Ana Cristina
dc.contributor.authorRelling, Alejandro Enrique
dc.contributor.authorShin, Sangsu
dc.contributor.authorLee, Sang Suk
dc.contributor.authorLee, Kichoon
dc.date.accessioned2018-06-11T17:32:33Z
dc.date.available2018-06-11T17:32:33Z
dc.date.issued2017-08
dc.date.updated2018-06-11T14:31:13Z
dc.description.abstractLipolysis is a catabolic reaction that is mediated by adipose triglyceride lipase (ATGL) and its inhibitor such as G0/G1 switch gene 2 (G0S2) protein during the first step of hydrolysis. The hydrophobic domain of G0S2 protein interacts and binds to the patatin-like domain in ATGL. Although conservation of the hydrophobic domain has been reported across species, sheep G0S2 amino acids and its hydrophobic domain have not been sequenced and studied. In this study, the hydrophobic region of G0S2 which plays an important role in inhibition of ATGL-mediated lipolysis was highly conserved as shown in other species. Phylogenetic analysis revealed that ruminant G0S2 proteins showed greater homologies within the ruminant species compared to other mammalian species. Moreover, adipose-specific expression of G0S2 for sheep was observed. Together with an abundant expression of ATGL protein in adipose tissue of sheep, G0S2 protein may play a critical role in inhibiting ATGL-mediated triacylglycerol (TAG) hydrolysis in the adipose tissue.es
dc.description.filFil: Ahn, Jinsoo. Ohio University; Estados Unidos
dc.description.filFil: Wu, Huiguang. Ohio University; Estados Unidos. Inner Mongolia University for Nationalities; China
dc.description.filFil: Suh, Yeunsu. Ohio University; Estados Unidos
dc.description.filFil: Carranza Martin, Ana Cristina. Ohio University; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.filFil: Relling, Alejandro Enrique. Ohio University; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.filFil: Shin, Sangsu. Kyungpook National University; Corea del Sur
dc.description.filFil: Lee, Sang Suk. Ohio University; Estados Unidos. Sunchon National University; Corea del Sur
dc.description.filFil: Lee, Kichoon. Ohio University; Estados Unidos
dc.formatapplication/pdfes
dc.identifier.citationAhn, Jinsoo; Wu, Huiguang; Suh, Yeunsu; Carranza Martin, Ana Cristina; Relling, Alejandro Enrique; et al.; Comparative sequence analysis and adipose-specific expression of G0S2 and ATGL in sheep; Elsevier Science; Journal of Small Ruminant Research; 153; 8-2017; 1-4es
dc.identifier.institucionalCONICET
dc.identifier.issn0921-4488es
dc.identifier.repoCONICET Digital
dc.identifier.urihttp://hdl.handle.net/11336/48104
dc.journal.ciudadAmsterdames
dc.journal.pagination1-4es
dc.journal.paisPaíses Bajoses
dc.journal.titleJournal of Small Ruminant Researches
dc.journal.volume153es
dc.language.isoenges
dc.publisherElsevier Sciencees
dc.relation.alternativeidinfo:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1016/j.smallrumres.2017.05.001
dc.relation.alternativeidinfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0921448817301207
dc.rightsinfo:eu-repo/semantics/openAccess*
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/*
dc.subjectSheepes
dc.subjectG0s2es
dc.subjectAtgles
dc.subjectAdipose Tissuees
dc.subject.classificationOtras Ciencias Veterinariases
dc.subject.classificationCiencias Veterinariases
dc.subject.classificationCIENCIAS AGRÍCOLASes
dc.titleComparative sequence analysis and adipose-specific expression of G0S2 and ATGL in sheepes
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion

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