The role of transforming growth factor (TGF)-β in modulating the immune response and fibrogenesis in the gut

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dc.conicet.organizacionUniversity of Pavia
dc.conicet.organizacionBarts and The London School of Medicine and Dentistry
dc.conicet.organizacionUniversity of Pavia
dc.conicet.organizacionUniversidad Nacional de La Plata
dc.conicet.organizacionConsejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Centro de Investigaciones en Criotecnología de Alimentos (i)
dc.conicet.organizacionBarts and The London School of Medicine and Dentistry
dc.conicet.organizacionUniversity of Pavia
dc.conicet.organizacionUniversity of Pavia
dc.conicet.paisOrganizacionItalia
dc.conicet.paisOrganizacionReino Unido
dc.conicet.paisOrganizacionItalia
dc.conicet.paisOrganizacionArgentina
dc.conicet.paisOrganizacionArgentina
dc.conicet.paisOrganizacionReino Unido
dc.conicet.paisOrganizacionItalia
dc.conicet.paisOrganizacionItalia
dc.conicet.produccionid2782068
dc.contributor.authorBiancheri, Paolo
dc.contributor.authorGiuffrida, Paolo
dc.contributor.authorDocena, Guillermo H.
dc.contributor.authorMacdonald, Thomas T.
dc.contributor.authorCorazza, Gino Roberto
dc.contributor.authorDi Sabatino, Antonio
dc.date.accessioned2016-12-26T20:15:13Z
dc.date.available2016-12-26T20:15:13Z
dc.date.issued2014-02
dc.date.updated2016-12-12T14:08:38Z
dc.description.abstractTransforming growth factor (TGF)-b, a pleiotropic cytokine released by both immune and non-immune cells in the gut, exerts an important tolerogenic action by promoting regulatory T cell differentiation. TGF-balso enhances enterocyte migration and regulates extracellular matrix turnover, thereby playing a crucial role in tissue remodeling in the gut. In this review we describe the mechanisms by which abnormal TGF-b signaling impairs intestinal immune tolerance and tissue repair, thus predisposing to the onset of immune-mediated bowel disorders, such as inflammatory bowel disease and celiac disease. Additionally, we will discuss potential therapeutic strategies aiming at restoring physiologic TGF-b signaling in chronic intestinal diseases.es
dc.description.filFil: Biancheri, Paolo. University of Pavia; Italia. Barts and The London School of Medicine and Dentistry; Reino Unido
dc.description.filFil: Giuffrida, Paolo. University of Pavia; Italia
dc.description.filFil: Docena, Guillermo H.. Universidad Nacional de La Plata; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Centro de Investigaciones en Criotecnología de Alimentos (i); Argentina
dc.description.filFil: Macdonald, Thomas T.. Barts and The London School of Medicine and Dentistry; Reino Unido
dc.description.filFil: Corazza, Gino Roberto. University of Pavia; Italia
dc.description.filFil: Di Sabatino, Antonio. University of Pavia; Italia
dc.formatapplication/pdfes
dc.identifier.citationBiancheri, Paolo; Giuffrida, Paolo; Docena, Guillermo H.; Macdonald, Thomas T.; Corazza, Gino Roberto; et al.; The role of transforming growth factor (TGF)-β in modulating the immune response and fibrogenesis in the gut; Elsevier; Cytokine & Growth Factor Reviews; 25; 1; 2-2014; 45-55es
dc.identifier.issn1359-6101es
dc.identifier.urihttp://hdl.handle.net/11336/10225
dc.journal.ciudadAmsterdames
dc.journal.number1es
dc.journal.pagination45-55es
dc.journal.paisPaíses Bajoses
dc.journal.titleCytokine & Growth Factor Reviewses
dc.journal.volume25es
dc.language.isoenges
dc.publisherElsevieres
dc.relation.alternativeidinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.cytogfr.2013.11.001
dc.relation.alternativeidinfo:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pubmed/24332927
dc.rightsinfo:eu-repo/semantics/openAccess*
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/es
dc.subjectCeliac Diseasees
dc.subjectCrohn´S Diseasees
dc.subjectMyofibroblastes
dc.subjectRregulatory T Celles
dc.subjectSmades
dc.subject.classificationOtras Ciencias de la Saludes
dc.subject.classificationCiencias de la Saludes
dc.subject.classificationCIENCIAS MÉDICAS Y DE LA SALUDes
dc.titleThe role of transforming growth factor (TGF)-β in modulating the immune response and fibrogenesis in the gutes
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion

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