Shelterin genes, germ line mutations and chronic lymphocytic leukemia

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dc.conicet.fuenteindividual
dc.conicet.organizacionConsejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental
dc.conicet.paisOrganizacionArgentina
dc.conicet.produccionid11116047
dc.contributor.authorSlavutsky, Irma Rosa
dc.date.accessioned2023-09-06T19:05:31Z
dc.date.available2023-09-06T19:05:31Z
dc.date.issued2017-02
dc.date.updated2023-09-05T12:10:31Z
dc.description.abstractTelomeres are distinctive DNA-protein structures that cap the ends of linear chromosomes; they are essential to maintain chromosomal integrity and genome stability. Telomeres are composed by tandem repeats of the non-codificant DNA sequence TTAGGG bound by the shelterin complex. It contains six core proteins: TERF1, TERF2, POT1, ACD, TERF2IP and TINF2, which play fundamental roles in telomere protection, chromosomal stability and regulation of telomere length (TL) (1). In addition, the shelterin complex modulates telomerase activity at chromosome ends, recognizes telomeric DNA and remodels it into a t-loop, which protects the 3? overhang from being recognized as DNA damage. Alterations in the structure and function of any of these proteins may lead to undesirable DNA damage responses that could be associated to a role in tumorigenesis and cancer progressiones
dc.description.filFil: Slavutsky, Irma Rosa. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
dc.formatapplication/pdfes
dc.identifier.citationSlavutsky, Irma Rosa; Shelterin genes, germ line mutations and chronic lymphocytic leukemia; AME Publishing Company; Translational Cancer Research; 6; S1; 2-2017; 68-71es
dc.identifier.institucionalCONICET
dc.identifier.issn2219-6803es
dc.identifier.repoCONICET Digital
dc.identifier.urihttp://hdl.handle.net/11336/210768
dc.journal.ciudadHong Konges
dc.journal.numberS1es
dc.journal.pagination68-71es
dc.journal.paisHong Konges
dc.journal.titleTranslational Cancer Researches
dc.journal.volume6es
dc.language.isoenges
dc.publisherAME Publishing Companyes
dc.relation.alternativeidinfo:eu-repo/semantics/altIdentifier/url/https://tcr.amegroups.org/article/view/12081/10301
dc.relation.alternativeidinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.21037/tcr.2017.02.36
dc.rightsinfo:eu-repo/semantics/openAccess*
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/*
dc.subjectCHRONIC LYMPHOCYTIC LEUKEMIAes
dc.subjectGERM LINE MUTATIONSes
dc.subjectSHELTERIN GENESes
dc.subject.classificationGenética Humanaes
dc.subject.classificationMedicina Básicaes
dc.subject.classificationCIENCIAS MÉDICAS Y DE LA SALUDes
dc.titleShelterin genes, germ line mutations and chronic lymphocytic leukemiaes
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion

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