Bactericidal and Hemolytic Activities of Synthetic Peptides Derived from Granulysin
; Tonarelli, Georgina Guadalupe ; Imaz, María Susana ; Perín, Juan Carlos ; Ruggeri, María Natalia ; Lopez, M. ; Santi, Maria Noemi ; Zerbini, Elsa Virginia Otros responsables
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04/2010
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Bentham Science Publishers
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Protein and Peptide Letters
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0929-8665
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Inglés
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Granulysin is a human polypeptide produced by cytolytic cells active against a broad range of microbes. Three peptides covering the regions 25-50 (Gr-1 and Gr-2) and 39-62 (Gr-3) of granulysin were synthesized, and their in vitro activity against Mycobacterium tuberculosis was evaluated. The most active peptide was Gr-1C, containing a disulphide bridge, with Minimal Inhibitory Concentration value of 10.1 μM. In concentrations of up to 50 μM, Gr-1 and Gr2 didn't exceed 30% of hemolysis.
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Siano, Alvaro Sebastían; Tonarelli, Georgina Guadalupe; Imaz, María Susana; Perín, Juan Carlos; Ruggeri, María Natalia; et al.; Bactericidal and Hemolytic Activities of Synthetic Peptides Derived from Granulysin; Bentham Science Publishers; Protein and Peptide Letters; 17; 4; 4-2010; 517-521
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