Comparative xenobiotic biotransformation in precission-cut liver slices from swine and cattle

Abstract

Species differences in the pattern of metabolism of foreign compounds is a key issue for veterinary practitioners. Comparative studies on the in vitro hepatic metabolism of xenobiotics among different farm animals requires the use of consistent and robust methodologies. The aim of the current work was to validate the technique of precision-cut liver slices (LSs) for comparative studies on xenobiotic metabolism in swine and cattle.