The anti-inflammatory effect of Phospholipase D 2 inhibition in an endotoxin-induced uveitis model
; Ho, Bo Man ; Fermento, María Eugenia ; Bermudez, Vicente ; Lin, Du ; Chu, Wai Kit ; Mateos, Melina Valeria Otros responsables
Fecha
2025
Editorial
The Association for Research in Vision and Ophthalmology
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Título del libro
Nombre del evento
2025 Association for Research in Vision and Ophthalmology Annual Meeting
Fecha del evento
2025-05-04
Institución organizadora
Association for Research in Vision and Ophthalmology
ISSN
1552-5783
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Inglés
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Resumen
Purpose : Uveitis is an ocular inflammatory disease affecting the uveal tract and adjacent ocular structures, including the retina and the vitreous. This condition is estimated to account for ∼25% of blindness in developed countries. Our previous results demonstrated that the Phospholipase D (PLD) pathway mediates the inflammatory response of retinal pigment epithelium cells induced by lipopolysaccharide (LPS). This study aims to investigate the effects of PLD2 inhibition in ocular inflammation using an endotoxin-induced uveitis (EIU) animal model.
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