Sensitivity to chirality correlates in a continuum with protein disorder

Abstract

Intrinsically disordered proteins (IDPs) exist as dynamic conformational ensembles the behavior of which challenges the tenets of the protein structure-function paradigm. In a new study, Newcombe, Due et al. reveal a striking continuum in sensitivity to chirality: while folded complexes are under strong chiral constraints, progressively disordered complexes show decreased sensitivity to chirality.