Artículo

Deactivation of Novozym® 435 during the esterification of ibuprofen with ethanol: Evidences of the detrimental effect of the alcohol

José, Carla Icon; Briand, Laura Estefania Icon

Otros responsables

Fecha

02/2010

Editorial

Springer

Revista

Reaction Kinetics, Mechanisms and Catalysis

Título del libro

Nombre del evento

Fecha del evento

Institución organizadora

ISSN

1878-5190

eISSN

1588-2837

ISBN

Idioma

Inglés

Tipo del evento

Resumen

The stability of Novozym® 435 in the esterification of ibuprofen using ethanol as reactant and solvent was investigated. Additionally, the surface interaction of the isomers of ibuprofen and ethanol with the biocatalyst was screened through conventional adsorption isotherms and temperature programmed surface reaction (TPSR). These investigations evidenced strong alcohol adsorption and dissolution of the biocatalyst, which explains its deactivation upon reuses in the esterification reaction.

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