An efficient synthetic methodology for the preparation of glycosyl β‐diketones

Abstract

In this study, we present a synthetic methodology for preparing glycosyl β-diketones from the corresponding allyl ethers. The process involves three steps: nitrile oxide cycloadditions, reduction of the glycosyl isoxazolines, and oxidation of β-hydroxyketones. This route is suitable for acid- and base-sensitive protecting groups, and the reactions were conducted with retention of the anomeric configuration. The resulting glycosyl β-diketones were then utilized in the synthesis of the corresponding pyrazoles.