Histamine receptors and cancer pharmacology

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dc.conicet.organizacionConsejo Nacional de Investigaciones Científicas y Técnicas
dc.conicet.organizacionUniversidad de Buenos Aires. Facultad de Farmacia y Bioquímica
dc.conicet.organizacionUniversidad de Buenos Aires. Facultad de Farmacia y Bioquímica
dc.conicet.paisOrganizacionArgentina
dc.conicet.paisOrganizacionArgentina
dc.conicet.paisOrganizacionArgentina
dc.conicet.produccionid4890551
dc.contributor.authorMedina, Vanina Araceli
dc.contributor.authorRivera, Elena S.
dc.date.accessioned2017-03-27T14:30:44Z
dc.date.available2017-03-27T14:30:44Z
dc.date.issued2010-10
dc.date.updated2017-03-21T20:12:00Z
dc.description.abstractConsiderable evidence has been collected indicating that histamine can modulate proliferation of different normal and malignant cells. High histamine biosynthesis and content together with histamine receptors have been reported in different human neoplasias including melanoma, colon and breast cancer, as well as in experimental tumours in which histamine has been postulated to behave as an important paracrine and autocrine regulator of proliferation. The discovery of the human histamine H(4) receptor in different tissues has contributed to our understanding of histamine role in numerous physiological and pathological conditions revealing novel functions for histamine and opening new perspectives in histamine pharmacology research. In the present review we aimed to briefly summarize current knowledge on histamine and histamine receptor involvement in cancer before focusing on some recent evidence supporting the novel role of histamine H(4) receptor in cancer progression representing a promising molecular target and avenue for cancer drug development.es
dc.description.filFil: Medina, Vanina Araceli. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
dc.description.filFil: Rivera, Elena S.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
dc.formatapplication/pdfes
dc.identifier.citationMedina, Vanina Araceli; Rivera, Elena S.; Histamine receptors and cancer pharmacology; Wiley; British Journal of Pharmacology; 161; 4; 10-2010; 755-767es
dc.identifier.issn0007-1188
dc.identifier.urihttp://hdl.handle.net/11336/14251
dc.journal.ciudadHobokenes
dc.journal.number4es
dc.journal.pagination755-767es
dc.journal.paisEstados Unidoses
dc.journal.titleBritish Journal of Pharmacologyes
dc.journal.volume161es
dc.language.isoenges
dc.publisherWileyes
dc.relation.alternativeidinfo:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2010.00961.x/abstract
dc.relation.alternativeidinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/j.1476-5381.2010.00961.x
dc.rightsinfo:eu-repo/semantics/openAccess*
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/es
dc.subjectHistaminees
dc.subjectHistamine H4 Receptores
dc.subjectCancer Pharmacologyes
dc.subjectBreast Canceres
dc.subjectMelanomaes
dc.subjectColon Canceres
dc.subjectHistamine H4 Receptor Ligandses
dc.subjectAnticancer Drugses
dc.subjectCell Proliferationes
dc.subjectMalignancyes
dc.subject.classificationOncologíaes
dc.subject.classificationMedicina Clínicaes
dc.subject.classificationCIENCIAS MÉDICAS Y DE LA SALUDes
dc.titleHistamine receptors and cancer pharmacologyes
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion

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