Successful management with fosfomycin + ceftazidime of an infection caused by multiple highly-related subtypes of multidrug-resistant and extensively drug-resistant KPC-producing Serratia marcescens

Abstract

Multidrug (MDR) and extensively drug resistant (XDR) S. marcescens infections are increasing in several hospital wards around the world 1-3, probably due to the recent use of colistin to combat Gram-negative carbapenem-resistant isolates 1,3,4. Here, we describe a particular case of S. marcescens infection from a single patient (P1) during four months of hospitalization. Nine S. marcescens strains, isolated from consecutive bone and soft tissue samples of P1, were subjected to antibiotype and molecular studies.