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dc.contributor.author
Rosignoli, F.
dc.contributor.author
Torroba, M.
dc.contributor.author
Juarranz, Y.
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García Gómez, M.
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Martinez, C.
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Gomariz, R. P.
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Perez Leiros, Claudia
dc.contributor.author
Leceta, J.
dc.date.available
2020-03-12T20:41:43Z
dc.date.issued
2006-12
dc.identifier.citation
Rosignoli, F.; Torroba, M.; Juarranz, Y.; García Gómez, M.; Martinez, C.; et al.; VIP and tolerance induction in autoimmunity; Blackwell Publishing; Annals of the New York Academy of Sciences; 1070; 12-2006; 525-530
dc.identifier.issn
0077-8923
dc.identifier.uri
http://hdl.handle.net/11336/99385
dc.description.abstract
Vasoactive intestinal peptide (VIP) is a potent antiinflammatory agent with immunoregulatory properties, skewing the immune response to a Th2 pattern of cytokine production. Here, we studied the effect of treatment with VIP in the development of diabetes in nonobese diabetic (NOD) mice, an annual model of type 1 diabetes. Mice treated with VIP from 4 weeks of age did not develop diabetes and showed milder insulitis than nontreated mice. The protective mechanism of VIP was associated with a reduction in the circulating levels of Th1 cytokines. In the pancreas of VIP-treated animals, regulatory T cell markers predominate, as indicated by the upregulation of FoxP3 and transforming growth factor-β (TGF-β), and the downregulation of the transcription factor, T-bet. These findings indicate that VIP restores tolerance to pancreatic islets by promoting the local differentiation and function of regulatory T cells.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Blackwell Publishing
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
AUTOIMMUNE
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FOXP3
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TGF-Β
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VIP
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Farmacología y Farmacia
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
VIP and tolerance induction in autoimmunity
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-02-13T20:09:03Z
dc.journal.volume
1070
dc.journal.pagination
525-530
dc.journal.pais
Reino Unido
dc.journal.ciudad
Oxford
dc.description.fil
Fil: Rosignoli, F.. Universidad Complutense de Madrid; España
dc.description.fil
Fil: Torroba, M.. Universidad Complutense de Madrid; España
dc.description.fil
Fil: Juarranz, Y.. Universidad Complutense de Madrid; España
dc.description.fil
Fil: García Gómez, M.. Universidad Complutense de Madrid; España
dc.description.fil
Fil: Martinez, C.. Universidad Complutense de Madrid; España
dc.description.fil
Fil: Gomariz, R. P.. Universidad Complutense de Madrid; España
dc.description.fil
Fil: Perez Leiros, Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina
dc.description.fil
Fil: Leceta, J.. Universidad Complutense de Madrid; España
dc.journal.title
Annals of the New York Academy of Sciences
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://nyaspubs.onlinelibrary.wiley.com/doi/full/10.1196/annals.1317.073
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1196/annals.1317.073
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