Artículo
VIP and tolerance induction in autoimmunity
Rosignoli, F.; Torroba, M.; Juarranz, Y.; García Gómez, M.; Martinez, C.; Gomariz, R. P.; Perez Leiros, Claudia
; Leceta, J.
Fecha de publicación:
12/2006
Editorial:
Blackwell Publishing
Revista:
Annals of the New York Academy of Sciences
ISSN:
0077-8923
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Vasoactive intestinal peptide (VIP) is a potent antiinflammatory agent with immunoregulatory properties, skewing the immune response to a Th2 pattern of cytokine production. Here, we studied the effect of treatment with VIP in the development of diabetes in nonobese diabetic (NOD) mice, an annual model of type 1 diabetes. Mice treated with VIP from 4 weeks of age did not develop diabetes and showed milder insulitis than nontreated mice. The protective mechanism of VIP was associated with a reduction in the circulating levels of Th1 cytokines. In the pancreas of VIP-treated animals, regulatory T cell markers predominate, as indicated by the upregulation of FoxP3 and transforming growth factor-β (TGF-β), and the downregulation of the transcription factor, T-bet. These findings indicate that VIP restores tolerance to pancreatic islets by promoting the local differentiation and function of regulatory T cells.
Palabras clave:
AUTOIMMUNE
,
FOXP3
,
TGF-Β
,
VIP
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Identificadores
Colecciones
Articulos(IQUIBICEN)
Articulos de INSTITUTO DE QUIMICA BIOLOGICA DE LA FACULTAD DE CS. EXACTAS Y NATURALES
Articulos de INSTITUTO DE QUIMICA BIOLOGICA DE LA FACULTAD DE CS. EXACTAS Y NATURALES
Citación
Rosignoli, F.; Torroba, M.; Juarranz, Y.; García Gómez, M.; Martinez, C.; et al.; VIP and tolerance induction in autoimmunity; Blackwell Publishing; Annals of the New York Academy of Sciences; 1070; 12-2006; 525-530
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