Artículo

Palladium-Catalyzed Direct C-H Arylation of 3-(Methylsulfinyl)thiophenes

Jiang, Hui; Bellomo Peraza, Ana InesIcon ; Zhang, Mengnan; Carroll, Patrick J.; Manor, Brian C.; Jia, Tiezheng; Walsh, Patrick J.
Fecha de publicación: 05/2018
Editorial: American Chemical Society
Revista: Organic Letters
ISSN: 1523-7060
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:

Resumen

A palladium-catalyzed direct arylation of (3-thiophene)S(O)Me derivatives has been developed. This protocol is effective for the selective synthesis of 2-arylated and 2,5-diarylated sulfinylthiophene derivatives with as low as 0.5 mol % catalyst loading. Various functional groups are well tolerated. A method to install two different aryl groups on 3-(methylsulfinyl)thiophenes is also introduced.
Palabras clave: DIRECT ARYLATION , HIGH THROUGHPUT SCREENING , SULFINYL THIOPHENES
 
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/98977
DOI: http://dx.doi.org/10.1021/acs.orglett.8b00599
URL: https://pubs.acs.org/doi/10.1021/acs.orglett.8b00599
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Citación
Jiang, Hui; Bellomo Peraza, Ana Ines; Zhang, Mengnan; Carroll, Patrick J.; Manor, Brian C.; et al.; Palladium-Catalyzed Direct C-H Arylation of 3-(Methylsulfinyl)thiophenes; American Chemical Society; Organic Letters; 20; 9; 5-2018; 2522-2525
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