Artículo
Synthesis of trisaccharides containing internal galactofuranose O-linked in Trypanosoma cruzi mucins
Fecha de publicación:
02/2010
Editorial:
Elsevier
Revista:
Carbohydrate Research
ISSN:
0008-6215
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
The trisaccharides β-d-Galf-(1→2)-β-d-Galf-(1→4)-d-GlcNAc (5) and β-d-Galp-(1→2)-β-d-Galf-(1→4)-d-GlcNAc (6) constitute novel structures isolated as alditols when released by reductive β-elimination from mucins of Trypanosoma cruzi (Tulahuen strain). Trisaccharides 5 and 6 were synthesized employing the aldonolactone approach. Thus, a convenient d-galactono-1,4-lactone derivative was used for the introduction of the internal galactofuranose and the trichloroacetimidate method was employed for glycosylation reactions. Due to the lack of anchimeric assistance on O-2 of the galactofuranosyl precursor, glycosylation studies were performed under different conditions. The nature of the solvent strongly determined the stereochemical course of the glycosylation reactions when the galactofuranosyl donor was substituted either by 2-O-Galp or 2-O-Galf.
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(CIHIDECAR)
Articulos de CENTRO DE INVESTIGACIONES EN HIDRATOS DE CARBONO
Articulos de CENTRO DE INVESTIGACIONES EN HIDRATOS DE CARBONO
Citación
Mendoza, Veronica Maria; Kashiwagi, Gustavo Adolfo; Muchnik, Rosa; Gallo, Carola; Synthesis of trisaccharides containing internal galactofuranose O-linked in Trypanosoma cruzi mucins; Elsevier; Carbohydrate Research; 345; 3; 2-2010; 385-396
Compartir
Altmétricas