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dc.contributor.author
Soria, Elio Andres
dc.contributor.author
Bongiovanni, Guillermina Azucena
dc.contributor.author
Díaz, Luján Cintia
dc.contributor.author
Eynard, Aldo Renato
dc.date.available
2016-12-20T20:30:07Z
dc.date.issued
2013-10
dc.identifier.citation
Soria, Elio Andres; Bongiovanni, Guillermina Azucena; Díaz, Luján Cintia; Eynard, Aldo Renato; Effect of Arsenic on Nitrosative Stress in Human Breast Cancer Cells and its Modulation by Flavonoids; Bentham Science Publishers; Current Pharmaceutical Design.; 67; 4; 10-2013; 1-4
dc.identifier.issn
1381-6128
dc.identifier.uri
http://hdl.handle.net/11336/9856
dc.description.abstract
Arsenic (As) is used in the treatment of leukaemia and breast cancer due to its strong oxidative cytotoxic action. However, it is also cytotoxic to normal cells. One proposed anticancer mechanism induced by As might be nitrosative stress (NS). Hence, it is believed that use of antioxidants such as flavonoids in combination with As might reduce its toxic action on normal cells without interfering with its antitumor action. In the present study, we evaluated the antineoplastic potential of As on breast human cancer lines MCF-7 and ZR- 75-1 treated with redox-modulating flavonoids, such as quercetin (Q) and silymarin (S). It was noted that, even though both cell lines differed in their oxidative responsiveness, their viability was decreased by NS induction through -glutamyltranspeptidase inhibition. Arsenic triggered NS in both MCF-7 and ZR-75-1 cultures, with the formers being more sensitive without recovering their pre-treatment capacity. ZR-75-1 cells maintained their antioxidant status, whereas MCF-7 ones treated with S, As and As+Q did not. Silymarin did not interfere with the described As bioactivity. In summary, NS appears as an important anticancer mechanism exerted by As depending on the redox cellular response that could be differentially modified by dietary antioxidants. Hence, it is worthwhile to consider the use of dietary antioxidants as adjuvant in cancer chemotherapy, especially when using As.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Bentham Science Publishers
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Arsenic
dc.subject
Breast Cancer
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Flavonoid
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Nitrosative Stress
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Quercetin
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Silymarin
dc.subject.classification
Biología Celular, Microbiología
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Effect of Arsenic on Nitrosative Stress in Human Breast Cancer Cells and its Modulation by Flavonoids
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-12-19T18:19:34Z
dc.identifier.eissn
1873-4286
dc.journal.volume
67
dc.journal.number
4
dc.journal.pagination
1-4
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Sharjah
dc.description.fil
Fil: Soria, Elio Andres. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
dc.description.fil
Fil: Bongiovanni, Guillermina Azucena. Universidad Nacional del Comahue; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Díaz, Luján Cintia. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
dc.description.fil
Fil: Eynard, Aldo Renato. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
dc.journal.title
Current Pharmaceutical Design.
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1080/01635581.2015.1019637
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.tandfonline.com/doi/abs/10.1080/01635581.2015.1019637?journalCode=hnuc20
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