Artículo
Effect of Arsenic on Nitrosative Stress in Human Breast Cancer Cells and its Modulation by Flavonoids
Fecha de publicación:
10/2013
Editorial:
Bentham Science Publishers
Revista:
Current Pharmaceutical Design.
ISSN:
1381-6128
e-ISSN:
1873-4286
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Arsenic (As) is used in the treatment of leukaemia and breast cancer due to its strong oxidative cytotoxic action. However, it is also cytotoxic to normal cells. One proposed anticancer mechanism induced by As might be nitrosative stress (NS). Hence, it is believed that use of antioxidants such as flavonoids in combination with As might reduce its toxic action on normal cells without interfering with its antitumor action. In the present study, we evaluated the antineoplastic potential of As on breast human cancer lines MCF-7 and ZR- 75-1 treated with redox-modulating flavonoids, such as quercetin (Q) and silymarin (S). It was noted that, even though both cell lines differed in their oxidative responsiveness, their viability was decreased by NS induction through -glutamyltranspeptidase inhibition. Arsenic triggered NS in both MCF-7 and ZR-75-1 cultures, with the formers being more sensitive without recovering their pre-treatment capacity. ZR-75-1 cells maintained their antioxidant status, whereas MCF-7 ones treated with S, As and As+Q did not. Silymarin did not interfere with the described As bioactivity. In summary, NS appears as an important anticancer mechanism exerted by As depending on the redox cellular response that could be differentially modified by dietary antioxidants. Hence, it is worthwhile to consider the use of dietary antioxidants as adjuvant in cancer chemotherapy, especially when using As.
Palabras clave:
Arsenic
,
Breast Cancer
,
Flavonoid
,
Nitrosative Stress
,
Quercetin
,
Silymarin
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(PROBIEN)
Articulos de INST. DE INVESTIGACION Y DES. EN ING. DE PROCESOS, BIOTECNOLOGIA Y ENERGIAS ALTERNATIVAS
Articulos de INST. DE INVESTIGACION Y DES. EN ING. DE PROCESOS, BIOTECNOLOGIA Y ENERGIAS ALTERNATIVAS
Citación
Soria, Elio Andres; Bongiovanni, Guillermina Azucena; Díaz, Luján Cintia; Eynard, Aldo Renato; Effect of Arsenic on Nitrosative Stress in Human Breast Cancer Cells and its Modulation by Flavonoids; Bentham Science Publishers; Current Pharmaceutical Design.; 67; 4; 10-2013; 1-4
Compartir
Altmétricas