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dc.contributor.author
Rosenthal, Victor Daniel  
dc.contributor.author
Udwadia, Farokh Earch  
dc.contributor.author
Kumar, Siva  
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Poojary, Aruna  
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Sankar, Rathi  
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Orellano, Pablo Wenceslao  
dc.contributor.author
Durgad, Shilpa  
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Thulasiraman, Mahendran  
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Bahirune, Shweta  
dc.contributor.author
Kumbhar, Shubhangi  
dc.contributor.author
Patil, Priyanka  
dc.date.available
2020-02-13T20:45:28Z  
dc.date.issued
2015-10  
dc.identifier.citation
Rosenthal, Victor Daniel; Udwadia, Farokh Earch; Kumar, Siva; Poojary, Aruna; Sankar, Rathi; et al.; Clinical impact and cost-effectiveness of split-septum and single-use prefilled flushing device vs 3-way stopcock on central line-associated bloodstream infection rates in India: A randomized clinical trial conducted by the International Nosocomial Infection Control Consortium (INICC); Mosby-Elsevier; American Journal Of Infection Control; 43; 10; 10-2015; 1040-1045  
dc.identifier.issn
0196-6553  
dc.identifier.uri
http://hdl.handle.net/11336/97495  
dc.description.abstract
Background Three-way stopcocks (3WSCs) are open systems used on intravenous tubing. Split septums (SSs) are closed systems with prepierced septums. Single-use prefilled flushing devices (SUFs) carry a lower risk of contamination than standard intravenous flushing. 3WSC and standard flushing are widely used in developing countries. This is the first randomized clinical trial (RCT) to compare rates of central line-associated bloodstream infection (CLABSI) between patients using an SS + SUF and those using a 3WSC. Methods An RCT with 1096 patients in 5 adult intensive care units was conducted between April 2012 and August 2014 to evaluate their impact on CLABSI rates. Centers for Disease Control and Prevention/National Healthcare Safety Network definitions were applied and International Nosocomial Infection Control Consortium methodology were followed. Results The study cohort included 547 patients and 3619 central line (CL)-days for the SS + SUF group, and 549 patients and 4061 CL-days for the 3WSC group. CLABSI rates were 2.21 per 1000 CL-days for SS + SUF and 6.40 per 1000 CL-days for 3WSC (relative risk, 0.35; 95% confidence interval [CI], 0.16-0.76; P =.006). The SS + SUF group had significantly better cumulative infection-free catheter survival compared with the 3WSC group (hazard ration, 0.33; 95% CI, 0.15-0.73; P =.006). Using an SS + SUF represents savings of $402.88 and an increase in quality-adjusted life years of 0.0008 per patient. For each extra dollar invested in an SS + SUF, $124 was saved. Conclusion The use of SS + SUF is cost-effective and associated with a significantly lower CLABSI rate compared with the use of 3WSC.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Mosby-Elsevier  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
BACTEREMIA  
dc.subject
CATHETER-RELATED INFECTION  
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DEVELOPING COUNTRIES  
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HEALTH CARE-ACQUIRED INFECTION  
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HOSPITAL INFECTION  
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INTENSIVE CARE UNIT  
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RANDOMIZED CLINICAL TRIAL  
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SINGLE-USE PREFILLED FLUSHING DEVICE  
dc.subject
SPLIT SEPTUM  
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THREE-WAY STOPCOCK  
dc.subject.classification
Otras Medicina Clínica  
dc.subject.classification
Medicina Clínica  
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CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Clinical impact and cost-effectiveness of split-septum and single-use prefilled flushing device vs 3-way stopcock on central line-associated bloodstream infection rates in India: A randomized clinical trial conducted by the International Nosocomial Infection Control Consortium (INICC)  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2019-12-27T14:04:43Z  
dc.journal.volume
43  
dc.journal.number
10  
dc.journal.pagination
1040-1045  
dc.journal.pais
Estados Unidos  
dc.description.fil
Fil: Rosenthal, Victor Daniel. Comunidad Científica Internacional de Control de Infecciones Nosocomiales; Argentina  
dc.description.fil
Fil: Udwadia, Farokh Earch. Breach Candy Hospital Trust; India  
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Fil: Kumar, Siva. Kovai Medical Center and Hospital; India  
dc.description.fil
Fil: Poojary, Aruna. Breach Candy Hospital Trust; India  
dc.description.fil
Fil: Sankar, Rathi. Kovai Medical Center and Hospital; India  
dc.description.fil
Fil: Orellano, Pablo Wenceslao. Comunidad Científica Internacional de Control de Infecciones Nosocomiales; Argentina. Universidad Tecnológica Nacional. Facultad Regional San Nicolás; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
dc.description.fil
Fil: Durgad, Shilpa. Breach Candy Hospital Trust; India  
dc.description.fil
Fil: Thulasiraman, Mahendran. Kovai Medical Center and Hospital; India  
dc.description.fil
Fil: Bahirune, Shweta. Breach Candy Hospital Trust; India  
dc.description.fil
Fil: Kumbhar, Shubhangi. Breach Candy Hospital Trust; India  
dc.description.fil
Fil: Patil, Priyanka. Breach Candy Hospital Trust; India  
dc.journal.title
American Journal Of Infection Control  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0196655315006550  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.ajic.2015.05.042