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Artículo

Clinical impact and cost-effectiveness of split-septum and single-use prefilled flushing device vs 3-way stopcock on central line-associated bloodstream infection rates in India: A randomized clinical trial conducted by the International Nosocomial Infection Control Consortium (INICC)

Rosenthal, Victor Daniel; Udwadia, Farokh Earch; Kumar, Siva; Poojary, Aruna; Sankar, Rathi; Orellano, Pablo WenceslaoIcon ; Durgad, Shilpa; Thulasiraman, Mahendran; Bahirune, Shweta; Kumbhar, Shubhangi; Patil, Priyanka
Fecha de publicación: 10/2015
Editorial: Mosby-Elsevier
Revista: American Journal Of Infection Control
ISSN: 0196-6553
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Otras Medicina Clínica

Resumen

Background Three-way stopcocks (3WSCs) are open systems used on intravenous tubing. Split septums (SSs) are closed systems with prepierced septums. Single-use prefilled flushing devices (SUFs) carry a lower risk of contamination than standard intravenous flushing. 3WSC and standard flushing are widely used in developing countries. This is the first randomized clinical trial (RCT) to compare rates of central line-associated bloodstream infection (CLABSI) between patients using an SS + SUF and those using a 3WSC. Methods An RCT with 1096 patients in 5 adult intensive care units was conducted between April 2012 and August 2014 to evaluate their impact on CLABSI rates. Centers for Disease Control and Prevention/National Healthcare Safety Network definitions were applied and International Nosocomial Infection Control Consortium methodology were followed. Results The study cohort included 547 patients and 3619 central line (CL)-days for the SS + SUF group, and 549 patients and 4061 CL-days for the 3WSC group. CLABSI rates were 2.21 per 1000 CL-days for SS + SUF and 6.40 per 1000 CL-days for 3WSC (relative risk, 0.35; 95% confidence interval [CI], 0.16-0.76; P =.006). The SS + SUF group had significantly better cumulative infection-free catheter survival compared with the 3WSC group (hazard ration, 0.33; 95% CI, 0.15-0.73; P =.006). Using an SS + SUF represents savings of $402.88 and an increase in quality-adjusted life years of 0.0008 per patient. For each extra dollar invested in an SS + SUF, $124 was saved. Conclusion The use of SS + SUF is cost-effective and associated with a significantly lower CLABSI rate compared with the use of 3WSC.
Palabras clave: BACTEREMIA , CATHETER-RELATED INFECTION , DEVELOPING COUNTRIES , HEALTH CARE-ACQUIRED INFECTION , HOSPITAL INFECTION , INTENSIVE CARE UNIT , RANDOMIZED CLINICAL TRIAL , SINGLE-USE PREFILLED FLUSHING DEVICE , SPLIT SEPTUM , THREE-WAY STOPCOCK
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/97495
URL: http://www.sciencedirect.com/science/article/pii/S0196655315006550
DOI: http://dx.doi.org/10.1016/j.ajic.2015.05.042
Colecciones
Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Citación
Rosenthal, Victor Daniel; Udwadia, Farokh Earch; Kumar, Siva; Poojary, Aruna; Sankar, Rathi; et al.; Clinical impact and cost-effectiveness of split-septum and single-use prefilled flushing device vs 3-way stopcock on central line-associated bloodstream infection rates in India: A randomized clinical trial conducted by the International Nosocomial Infection Control Consortium (INICC); Mosby-Elsevier; American Journal Of Infection Control; 43; 10; 10-2015; 1040-1045
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