A 3D Cellular Automaton for Cell Differentiation in a Solid Tumor with Plasticity

Margarit, David Hipólito; Romanelli, Lilia Mabel; Fendrik, Alejandro José

doi:https://doi.org/10.1142/S1793048018500029

Artículo

A 3D Cellular Automaton for Cell Differentiation in a Solid Tumor with Plasticity

Margarit, David Hipólito Icon

; Romanelli, Lilia Mabel Icon

; Fendrik, Alejandro José Icon

Fecha de publicación: 04/2018

Editorial: World Scientific

Revista: Biophysical Reviews and Letters

ISSN: 1793-7035

Idioma: Inglés

Tipo de recurso: Artículo publicado

Clasificación temática:

Otras Ciencias Físicas

Resumen

A model with spherical symmetry is proposed. We analyze the appropriate parameters of cell dierentiation for different kinds of cells (Cancer Stem Cells (CSC) and Differentiated Cells(DC)). The plasticity (capacity to return from a DC to its previous state of CSC) is taken intoaccount. Following this hypothesis, the dissemination of CSCs to another organ is analyzed. The location of the cells in the tumor and the plasticity range for possible metastasis is discussed.

Palabras clave: Celular automaton , Cell differentiation , Cancer stem cells , Plasticity

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Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)

Identificadores

URI: http://hdl.handle.net/11336/97379

URL: https://www.worldscientific.com/doi/abs/10.1142/S1793048018500029

DOI: https://doi.org/10.1142/S1793048018500029

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Citación

Margarit, David Hipólito; Romanelli, Lilia Mabel; Fendrik, Alejandro José; A 3D Cellular Automaton for Cell Differentiation in a Solid Tumor with Plasticity; World Scientific; Biophysical Reviews and Letters; 13; 01; 4-2018; 19-28

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