Artículo
MccJ25 C-terminal is involved in RNA-polymerase inhibition but not in respiration inhibition
Vincent, Paula Andrea
; Bellomio, Augusto
; Fernandez, Beatriz Eugenia
; Farias, Ricardo Norberto
; Morero, Roberto Dionisio
Fecha de publicación:
06/2005
Editorial:
Academic Press Inc Elsevier Science
Revista:
Biochemical and Biophysical Research Communications
ISSN:
0006-291X
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Microcin J25 appears to have two intracellular targets: (1) RNA polymerase, which was described in Escherichia coli and Salmonella enterica serovars, and (2) cell respiration in Salmonella enterica serovars. C-terminal glycine amidation of the threaded segment localized in the MccJ25 lariat ring region specifically blocked the RNA-polymerase inhibition, but not the cell respiration inhibition and peptide uptake. These results suggest that different regions of the molecule are responsible for each cellular effect, they are localized far away from the β-hairpin region and the C-terminal region is an important determinant for RNAP inhibition.
Palabras clave:
MCCJ25 AMIDATED DERIVATIVE
,
MICROCIN J25
,
OXYGEN CONSUMPTION
,
RNA POLYMERASE
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(INSIBIO)
Articulos de INST.SUP.DE INVEST.BIOLOGICAS
Articulos de INST.SUP.DE INVEST.BIOLOGICAS
Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Articulos de SEDE CENTRAL
Citación
Vincent, Paula Andrea; Bellomio, Augusto; Fernandez, Beatriz Eugenia; Farias, Ricardo Norberto; Morero, Roberto Dionisio; MccJ25 C-terminal is involved in RNA-polymerase inhibition but not in respiration inhibition; Academic Press Inc Elsevier Science; Biochemical and Biophysical Research Communications; 331; 2; 6-2005; 549-551
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