Hyaluronan induces migration of multidrug-resistant lymphoma cell lines in vitro through Tiam1 activation by a PI3K-dependent mechanism

Hyaluronan (HA) modulates multidrug resistance (MDR) as well as cell migration. Tiam1 is involved in cytoskeleton reorganization during tumor invasion. In this report we show the relationship among HA, Tiam1, migration and MDR in murine lymphoma cell lines. We observed that MDR cells presented higher migratory capacity towards HA in vitro as well as higher constitutive active Tiam1 expression than the sensitive cell line. Besides, HA treatment induced migration towards HA of MDR cell lines through Tiam1 activation by a PI3K-dependent mechanism, showing that disruption of HA signaling would be useful in treatment of MDR hematological malignancies.

Palabras clave: Hyaluronan , Tiam1 , Migration , Multidrug Resistance , Lymphoma

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Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)

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URI: http://hdl.handle.net/11336/94550

URL: https://www.sciencedirect.com/science/article/pii/S0145212610001037

DOI: http://dx.doi.org/10.1016/j.leukres.2010.02.020

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Articulos(IBYME)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)

Articulos(IDEHU)
Articulos de INST.DE EST.DE LA INMUNIDAD HUMORAL PROF.R.A.MARGNI

Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL

Citación

Cordo Russo, Rosalia Ines; Alaniz, Laura Daniela; Saccodossi, Natalia; Lompardía, Silvina Laura; Blanco, Guillermo Armando C.; et al.; Hyaluronan induces migration of multidrug-resistant lymphoma cell lines in vitro through Tiam1 activation by a PI3K-dependent mechanism; Pergamon-Elsevier Science Ltd; Leukemia Research; 34; 11; 11-2010; 1525-1532

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