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dc.contributor.author
Keller, Elizabeth Ana  
dc.contributor.author
Zamparini, A.  
dc.contributor.author
Borodinsky, L.N.  
dc.contributor.author
Gravielle, Maria Clara  
dc.contributor.author
Fiszman, Monica Lidia  
dc.date.available
2020-01-10T20:34:49Z  
dc.date.issued
2004-10  
dc.identifier.citation
Keller, Elizabeth Ana; Zamparini, A.; Borodinsky, L.N.; Gravielle, Maria Clara; Fiszman, Monica Lidia; Role of allopregnanolone on cerebellar granule cells neurogenesis; Elsevier; Developmental Brain Research; 153; 1; 10-2004; 13-17  
dc.identifier.issn
0165-3806  
dc.identifier.uri
http://hdl.handle.net/11336/94394  
dc.description.abstract
The role of allopregnanolone on immature cerebellar granule cells (CGC) proliferation was studied. Allopregnanolone (0.1–1 μM) increased [3H]thymidine incorporation and cell number determined by neuronal counting and by an MTT colorimetric assay. The effect of the neurosteroid was completely prevented by preincubation with 10 mM MgCl2, 10 μM nifedipine, 10 μM picrotoxin or by 50 μM bicuculine. We conclude that ALLO affects cerebellar neurogenesis by increasing calcium influx through voltage-gated calcium channels and GABAA receptors activation.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Elsevier  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
ALLOPREGNANOLONE  
dc.subject
CALCIUM  
dc.subject
CEREBELLUM  
dc.subject
GABA A RECEPTOR  
dc.subject
NEUROGENESIS  
dc.subject
PROLIFERATION  
dc.subject.classification
Otros Tópicos Biológicos  
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Ciencias Biológicas  
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CIENCIAS NATURALES Y EXACTAS  
dc.title
Role of allopregnanolone on cerebellar granule cells neurogenesis  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2019-11-25T17:47:06Z  
dc.journal.volume
153  
dc.journal.number
1  
dc.journal.pagination
13-17  
dc.journal.pais
Países Bajos  
dc.journal.ciudad
Amsterdam  
dc.description.fil
Fil: Keller, Elizabeth. ININFA; Argentina  
dc.description.fil
Fil: Zamparini, Andrea. ININFA; Argentina  
dc.description.fil
Fil: Borodinski, Laura. FACULTAD; Argentina  
dc.description.fil
Fil: Gravielle, Maria Clara. ININFA; Argentina  
dc.description.fil
Fil: Fiszman, Monica Lidia. ININFA; Argentina  
dc.journal.title
Developmental Brain Research  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0165380604002329  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.devbrainres.2004.07.009  

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