Artículo

Role of allopregnanolone on cerebellar granule cells neurogenesis

Keller, Elizabeth AnaIcon ; Zamparini, A.; Borodinsky, L.N.; Gravielle, Maria ClaraIcon ; Fiszman, Monica LidiaIcon
Fecha de publicación: 10/2004
Editorial: Elsevier
Revista: Developmental Brain Research
ISSN: 0165-3806
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:

Resumen

The role of allopregnanolone on immature cerebellar granule cells (CGC) proliferation was studied. Allopregnanolone (0.1–1 μM) increased [3H]thymidine incorporation and cell number determined by neuronal counting and by an MTT colorimetric assay. The effect of the neurosteroid was completely prevented by preincubation with 10 mM MgCl2, 10 μM nifedipine, 10 μM picrotoxin or by 50 μM bicuculine. We conclude that ALLO affects cerebellar neurogenesis by increasing calcium influx through voltage-gated calcium channels and GABAA receptors activation.
Palabras clave: ALLOPREGNANOLONE , CALCIUM , CEREBELLUM , GABA A RECEPTOR , NEUROGENESIS , PROLIFERATION
 
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/94394
URL: https://www.sciencedirect.com/science/article/pii/S0165380604002329
DOI: http://dx.doi.org/10.1016/j.devbrainres.2004.07.009
Colecciones
Articulos(ININFA)
Articulos de INST.DE INVEST.FARMACOLOGICAS (I)
Citación
Keller, Elizabeth Ana; Zamparini, A.; Borodinsky, L.N.; Gravielle, Maria Clara; Fiszman, Monica Lidia; Role of allopregnanolone on cerebellar granule cells neurogenesis; Elsevier; Developmental Brain Research; 153; 1; 10-2004; 13-17
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