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dc.contributor.author
Hickman, Heather D.
dc.contributor.author
Mays, Jacqueline W.
dc.contributor.author
Gibbs, James
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Kosik, Ivan
dc.contributor.author
Magadan, Javier Guillermo
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dc.contributor.author
Takeda, Kazuyo
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Das, Suman
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Reynoso, Glennys V.
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Ngudiankama, Barbara F.
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Wei, Jiajie
dc.contributor.author
Shannon, John P.
dc.contributor.author
McManus, Daniel
dc.contributor.author
Yewdell, Jonathan W.
dc.date.available
2020-01-09T15:13:54Z
dc.date.issued
2018-08
dc.identifier.citation
Hickman, Heather D.; Mays, Jacqueline W.; Gibbs, James; Kosik, Ivan; Magadan, Javier Guillermo; et al.; Influenza A virus negative strand RNA is translated for CD8+ T cell immunosurveillance; American Association of Immunologists; Journal of Immunology; 201; 4; 8-2018; 1222-1228
dc.identifier.issn
0022-1767
dc.identifier.uri
http://hdl.handle.net/11336/94120
dc.description.abstract
Probing the limits of CD8+ T cell immunosurveillance, we inserted the SIINFEKL peptide into influenza A virus (IAV)-negative strand gene segments. Although IAV genomic RNA is considered noncoding, there is a conserved, relatively long open reading frame present in segment 8, encoding a potential protein termed NEG8. The biosynthesis of NEG8 from IAV has yet to be demonstrated. Although we failed to detect NEG8 protein expression in IAV-infected mouse cells, cell surface Kb-SIINFEKL complexes are generated when SIINFEKL is genetically appended to the predicted C terminus of NEG8, as shown by activation of OT-I T cells in vitro and in vivo. Moreover, recombinant IAV encoding of SIINFEKL embedded in the negative strand of the neuraminidase-stalk coding sequence also activates OT-I T cells in mice. Together, our findings demonstrate both the translation of sequences on the negative strand of a single-stranded RNAvirus and its relevance in antiviral immunosurveillance.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Association of Immunologists
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
INFLUENZA A
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NEG8
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IMMUNOSURVEILLANCE
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Virología
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dc.subject.classification
Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
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dc.title
Influenza A virus negative strand RNA is translated for CD8+ T cell immunosurveillance
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-10-23T19:30:26Z
dc.journal.volume
201
dc.journal.number
4
dc.journal.pagination
1222-1228
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
Bethesda
dc.description.fil
Fil: Hickman, Heather D.. National Institute Of Allergy And Infectious Diseases;
dc.description.fil
Fil: Mays, Jacqueline W.. National Institute Of Allergy And Infectious Diseases;
dc.description.fil
Fil: Gibbs, James. National Institute Of Allergy And Infectious Diseases;
dc.description.fil
Fil: Kosik, Ivan. National Institute Of Allergy And Infectious Diseases;
dc.description.fil
Fil: Magadan, Javier Guillermo. National Institute Of Allergy And Infectious Diseases; . Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo; Argentina
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Fil: Takeda, Kazuyo. Food And Drug Administration;
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Fil: Das, Suman. National Institute Of Allergy And Infectious Diseases;
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Fil: Reynoso, Glennys V.. National Institute Of Allergy And Infectious Diseases;
dc.description.fil
Fil: Ngudiankama, Barbara F.. National Institute Of Allergy And Infectious Diseases;
dc.description.fil
Fil: Wei, Jiajie. National Institute Of Allergy And Infectious Diseases;
dc.description.fil
Fil: Shannon, John P.. National Institute Of Allergy And Infectious Diseases;
dc.description.fil
Fil: McManus, Daniel. National Institute Of Allergy And Infectious Diseases;
dc.description.fil
Fil: Yewdell, Jonathan W.. National Institute Of Allergy And Infectious Diseases;
dc.journal.title
Journal of Immunology
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.4049/jimmunol.1800586
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.jimmunol.org/content/201/4/1222
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