Artículo
An integrative, multi-omics approach towards the prioritization of Klebsiella pneumoniae drug targets
Ramos, Pablo Ivan Pereira; Fernández Do Porto, Darío Augusto
; Lanzarotti, Esteban Omar
; Sosa, Ezequiel
; Burguener, Germán Federico
; Pardo, Agustin Maria
; Klein, Cecilia C.; Sagot, Marie-France; De Vasconcelos, Ana Tereza R.; Gales, Ana Cristina; Marti, Marcelo Adrian
; Turjanski, Adrian
; Nicolás, Marisa F.
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Fecha de publicación:
07/2018
Editorial:
Nature Publishing Group
Revista:
Scientific Reports
ISSN:
2045-2322
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Klebsiella pneumoniae (Kp) is a globally disseminated opportunistic pathogen that can cause life-threatening infections. It has been found as the culprit of many infection outbreaks in hospital environments, being particularly aggressive towards newborns and adults under intensive care. Many Kp strains produce extended-spectrum β-lactamases, enzymes that promote resistance against antibiotics used to fight these infections. The presence of other resistance determinants leading to multidrug-resistance also limit therapeutic options, and the use of 'last-resort' drugs, such as polymyxins, is not uncommon. The global emergence and spread of resistant strains underline the need for novel antimicrobials against Kp and related bacterial pathogens. To tackle this great challenge, we generated multiple layers of 'omics' data related to Kp and prioritized proteins that could serve as attractive targets for antimicrobial development. Genomics, transcriptomics, structuromic and metabolic information were integrated in order to prioritize candidate targets, and this data compendium is freely available as a web server. Twenty-nine proteins with desirable characteristics from a drug development perspective were shortlisted, which participate in important processes such as lipid synthesis, cofactor production, and core metabolism. Collectively, our results point towards novel targets for the control of Kp and related bacterial pathogens.
Palabras clave:
Klebsiella pneumoniae
,
bioinformática
,
genómica
,
drug discovery
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Articulos(IQUIBICEN)
Articulos de INSTITUTO DE QUIMICA BIOLOGICA DE LA FACULTAD DE CS. EXACTAS Y NATURALES
Articulos de INSTITUTO DE QUIMICA BIOLOGICA DE LA FACULTAD DE CS. EXACTAS Y NATURALES
Articulos(OCA CIUDAD UNIVERSITARIA)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA CIUDAD UNIVERSITARIA
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA CIUDAD UNIVERSITARIA
Citación
Ramos, Pablo Ivan Pereira; Fernández Do Porto, Darío Augusto; Lanzarotti, Esteban Omar; Sosa, Ezequiel; Burguener, Germán Federico; et al.; An integrative, multi-omics approach towards the prioritization of Klebsiella pneumoniae drug targets; Nature Publishing Group; Scientific Reports; 8; 1; 7-2018; 1-19
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