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dc.contributor.author
Martín, María Julia  
dc.contributor.author
Gigola, Graciela  
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Zwenger, Ariel  
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Carriquiriborde, Martin  
dc.contributor.author
Gentil, Florencia  
dc.contributor.author
Gentili, Claudia Rosana  
dc.date.available
2019-12-06T14:17:46Z  
dc.date.issued
2018-12-15  
dc.identifier.citation
Martín, María Julia; Gigola, Graciela; Zwenger, Ariel; Carriquiriborde, Martin; Gentil, Florencia; et al.; Potential therapeutic targets for growth arrest of colorectal cancer cells exposed to PTHrP; Elsevier Ireland; Molecular and Cellular Endocrinology; 478; 15-12-2018; 32-44  
dc.identifier.issn
0303-7207  
dc.identifier.uri
http://hdl.handle.net/11336/91603  
dc.description.abstract
Although PTHrP is implicated in several cancers, its role in chemoresistance is not fully elucidated. We found that in CRC cells, PTHrP exerts proliferative and protective effects and induces cell migration. The aim of this work was to further study the effects of PTHrP in CRC cells. Herein we evidenced, for the first time, that PTHrP induces resistance to CPT-11 in Caco-2 and HCT116 cells; although both cell lines responded to the drug through different molecular mechanisms, the chemoresistance by PTHrP in these models is mediated through ERK, which in turn is activated by PCK, Src and Akt. Moreover, continue administration of PTHrP in nude mice xenografts increased the protein levels of this MAPK and of other markers related to tumorigenic events. The understanding of the molecular mechanisms leading to ERK 1/2 activation and the study of ERK targets may facilitate the development of new therapeutic strategies for CRC treatment.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Elsevier Ireland  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights
Atribución-NoComercial-CompartirIgual 2.5 Argentina (CC BY-NC-SA 2.5 AR)  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
CHEMORESISTANCE  
dc.subject
COLORECTAL CANCER  
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MITOGENIC SIGNALING  
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MOLECULAR MECHANISMS  
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PTHRP  
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Oncología  
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Medicina Clínica  
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CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Potential therapeutic targets for growth arrest of colorectal cancer cells exposed to PTHrP  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2019-10-23T21:34:02Z  
dc.journal.volume
478  
dc.journal.pagination
32-44  
dc.journal.pais
Países Bajos  
dc.journal.ciudad
Amsterdam  
dc.description.fil
Fil: Martín, María Julia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Ciencias Biológicas y Biomédicas del Sur. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Instituto de Ciencias Biológicas y Biomédicas del Sur; Argentina  
dc.description.fil
Fil: Gigola, Graciela. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina  
dc.description.fil
Fil: Zwenger, Ariel. Hospital Provincial de Neuquén; Argentina  
dc.description.fil
Fil: Carriquiriborde, Martin. Universidad Nacional de La Plata; Argentina  
dc.description.fil
Fil: Gentil, Florencia. Universidad Nacional de La Plata; Argentina  
dc.description.fil
Fil: Gentili, Claudia Rosana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Ciencias Biológicas y Biomédicas del Sur. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Instituto de Ciencias Biológicas y Biomédicas del Sur; Argentina  
dc.journal.title
Molecular and Cellular Endocrinology  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0303720718302211  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.mce.2018.07.005