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dc.contributor.author
de Kloet, J. E. R.
dc.contributor.author
Meijer, Onno C.
dc.contributor.author
de Nicola, Alejandro Federico
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dc.contributor.author
de Rijk, Roel H.
dc.contributor.author
Joëls, Marian
dc.date.available
2019-11-30T22:46:55Z
dc.date.issued
2018-04
dc.identifier.citation
de Kloet, J. E. R.; Meijer, Onno C.; de Nicola, Alejandro Federico; de Rijk, Roel H.; Joëls, Marian; Importance of the brain corticosteroid receptor balance in metaplasticity, cognitive performance and neuro-inflammation; Academic Press Inc Elsevier Science; Frontiers In Neuroendocrinology; 49; 4-2018; 124-145
dc.identifier.issn
0091-3022
dc.identifier.uri
http://hdl.handle.net/11336/91060
dc.description.abstract
Bruce McEwen's discovery of receptors for corticosterone in the rat hippocampus introduced higher brain circuits in the neuroendocrinology of stress. Subsequently, these receptors were identified as mineralocorticoid receptors (MRs) that are involved in appraisal processes, choice of coping style, encoding and retrieval. The MR-mediated actions on cognition are complemented by slower actions via glucocorticoid receptors (GRs) on contextualization, rationalization and memory storage of the experience. These sequential phases in cognitive performance depend on synaptic metaplasticity that is regulated by coordinate MR- and GR activation. The receptor activation includes recruitment of coregulators and transcription factors as determinants of context-dependent specificity in steroid action; they can be modulated by genetic variation and (early) experience. Interestingly, inflammatory responses to damage seem to be governed by a similarly balanced MR:GR-mediated action as the initiating, terminating and priming mechanisms involved in stress-adaptation. We conclude with five questions challenging the MR:GR balance hypothesis.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Academic Press Inc Elsevier Science
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
AMYGDALA
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BRAIN
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COREGULATORS
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CORTISOL
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GLUCOCORTICOID RECEPTORS
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HIPPOCAMPUS
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INFLAMMATION
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MEMORY
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METAPLASTICITY
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MINERALOCORTICOID RECEPTORS
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NEUROD TRANSCRIPTION FACTOR
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STRESS
dc.subject.classification
Neurociencias
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Importance of the brain corticosteroid receptor balance in metaplasticity, cognitive performance and neuro-inflammation
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-10-17T15:43:32Z
dc.journal.volume
49
dc.journal.pagination
124-145
dc.journal.pais
Estados Unidos
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dc.description.fil
Fil: de Kloet, J. E. R.. Leiden University; Países Bajos
dc.description.fil
Fil: Meijer, Onno C.. Leiden University; Países Bajos
dc.description.fil
Fil: de Nicola, Alejandro Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil
Fil: de Rijk, Roel H.. Leiden University; Países Bajos
dc.description.fil
Fil: Joëls, Marian. University of Utrecht; Países Bajos. University of Groningen; Países Bajos
dc.journal.title
Frontiers In Neuroendocrinology
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0091302218300116?via%3Dihub
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/http://dx.doi.org/10.1016/j.yfrne.2018.02.003
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