Artículo
Importance of the brain corticosteroid receptor balance in metaplasticity, cognitive performance and neuro-inflammation
de Kloet, J. E. R.; Meijer, Onno C.; de Nicola, Alejandro Federico
; de Rijk, Roel H.; Joëls, Marian
![Icon](/themes/CONICETDigital/images/conicet.png)
Fecha de publicación:
04/2018
Editorial:
Academic Press Inc Elsevier Science
Revista:
Frontiers In Neuroendocrinology
ISSN:
0091-3022
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Bruce McEwen's discovery of receptors for corticosterone in the rat hippocampus introduced higher brain circuits in the neuroendocrinology of stress. Subsequently, these receptors were identified as mineralocorticoid receptors (MRs) that are involved in appraisal processes, choice of coping style, encoding and retrieval. The MR-mediated actions on cognition are complemented by slower actions via glucocorticoid receptors (GRs) on contextualization, rationalization and memory storage of the experience. These sequential phases in cognitive performance depend on synaptic metaplasticity that is regulated by coordinate MR- and GR activation. The receptor activation includes recruitment of coregulators and transcription factors as determinants of context-dependent specificity in steroid action; they can be modulated by genetic variation and (early) experience. Interestingly, inflammatory responses to damage seem to be governed by a similarly balanced MR:GR-mediated action as the initiating, terminating and priming mechanisms involved in stress-adaptation. We conclude with five questions challenging the MR:GR balance hypothesis.
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Articulos(IBYME)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Citación
de Kloet, J. E. R.; Meijer, Onno C.; de Nicola, Alejandro Federico; de Rijk, Roel H.; Joëls, Marian; Importance of the brain corticosteroid receptor balance in metaplasticity, cognitive performance and neuro-inflammation; Academic Press Inc Elsevier Science; Frontiers In Neuroendocrinology; 49; 4-2018; 124-145
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