Mostrar el registro sencillo del ítem

dc.contributor.author
Isla, Guillermina  
dc.contributor.author
Leonardelli, Florencia  
dc.contributor.author
Tiraboschi, Iris Nora  
dc.contributor.author
Refojo, Nicolás  
dc.contributor.author
Hevia, Alejandra  
dc.contributor.author
Vivot, Walter Oscar  
dc.contributor.author
Szusz, Wanda  
dc.contributor.author
Córdoba, Susana Beatríz  
dc.contributor.author
García Effron, Guillermo  
dc.date.available
2019-11-25T13:16:19Z  
dc.date.issued
2018-10  
dc.identifier.citation
Isla, Guillermina; Leonardelli, Florencia; Tiraboschi, Iris Nora; Refojo, Nicolás; Hevia, Alejandra; et al.; First clinical isolation of an azole-resistant aspergillus fumigatus isolate harboring a TR46 Y121F T289A mutation in South America; American Society for Microbiology; Antimicrobial Agents and Chemotherapy; 62; 10; 10-2018; 1-7  
dc.identifier.issn
0066-4804  
dc.identifier.uri
http://hdl.handle.net/11336/89641  
dc.description.abstract
One of the most recently described Aspergillus fumigatus CYP51Amediated azole resistance mechanisms is TR46 Y121F T289A. Clinical A. fumigatus strains harboring these substitutions have been reported worldwide, with the exception of South America. We describe the first clinical A. fumigatus strain with this resistance mechanism isolated from an Argentinian patient. The strain was isolated in 2009 (1 year after the first-described mutant in United States), demonstrating that these alleles were scattered worldwide earlier than previously thought.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
American Society for Microbiology  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
ASPERGILLUS FUMIGATUS  
dc.subject
AZOLE  
dc.subject
CYP51A  
dc.subject
RESISTANCE  
dc.subject
SOUTH AMERICA  
dc.subject
TR46  
dc.subject
TR46 Y121F T289A MUTATION  
dc.subject.classification
Biología Celular, Microbiología  
dc.subject.classification
Ciencias Biológicas  
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS  
dc.title
First clinical isolation of an azole-resistant aspergillus fumigatus isolate harboring a TR46 Y121F T289A mutation in South America  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2019-09-27T14:57:21Z  
dc.journal.volume
62  
dc.journal.number
10  
dc.journal.pagination
1-7  
dc.journal.pais
Estados Unidos  
dc.description.fil
Fil: Isla, Guillermina. Instituto Nacional de Enfermedades Infecciosas; Argentina  
dc.description.fil
Fil: Leonardelli, Florencia. Universidad Nacional del Litoral; Argentina  
dc.description.fil
Fil: Tiraboschi, Iris Nora. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
dc.description.fil
Fil: Refojo, Nicolás. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina  
dc.description.fil
Fil: Hevia, Alejandra. Instituto Nacional de Enfermedades Infecciosas; Argentina  
dc.description.fil
Fil: Vivot, Walter Oscar. Instituto Nacional de Enfermedades Infecciosas; Argentina  
dc.description.fil
Fil: Szusz, Wanda. Instituto Nacional de Enfermedades Infecciosas; Argentina  
dc.description.fil
Fil: Córdoba, Susana Beatríz. Instituto Nacional de Enfermedades Infecciosas; Argentina  
dc.description.fil
Fil: García Effron, Guillermo. Instituto Nacional de Enfermedades Infecciosas; Argentina  
dc.journal.title
Antimicrobial Agents and Chemotherapy  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://aac.asm.org/lookup/doi/10.1128/AAC.00872-18  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1128/AAC.00872-18  

Archivos asociados
Thumbnail
 
Tamaño: 605.4Kb
Formato: PDF
.