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Artículo

Differential effects of hypo- and hyperthyroidism on remodeling of contacts between neurons expressing the neuropeptide EI and tyrosine hydroxylase in hypothalamic areas of the male rat

Ayala, CarolinaIcon ; Pennacchio, Gisela ErikaIcon ; Soaje, MartaIcon ; Bittencourt Guimaraes, Ana Tereza; Celis, Marìa E.; Jahn, Graciela AlmaIcon ; Valdez, Susana RuthIcon ; Seltzer, Alicia MabelIcon
Fecha de publicación: 03/2019
Editorial: Elsevier Science Inc
Revista: Peptides
ISSN: 0196-9781
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Otras Ciencias Médicas

Resumen

The Neuropeptide EI (NEI, glutamic acid- isoleucine amide) participates in neuroendocrine function. Previously we demonstrated that NEI concentration is regulated by thyroid hormones in discrete hypothalamic areas in rats. We observed that the thyroid status affects the dopaminergic regulation of the pituitary hormones. In this study we explored possible interactions between NEI and tyrosine hydroxylase (TH) containing elements in selected hypothalamic areas of male rats. Neuronal somas, terminals and boutons were assessed by confocal microscopy, in hypo- and hyperthyroid animals. We observed a remodeling of the contacts between the TH and NEI immunoreactive elements in the incerto-hypothalamic area (IHy, also known as rostromedial zona incerta) according to thyroid function. However, in the dorsolateral zone of the peduncular part of the lateral hypothalamus (DL-PLH) the thyroid hormones affect the dendritic trees of the neurons without perturbing the overall NEI/TH contacts. Also, we demonstrated that TRH Receptor 1 (TRH-R1) is colocalized in NEI immunoreactive neurons in the peduncular part of the lateral hypothalamus (PLH) and NEI precursor mRNA expression increased by hypothyroidism indicating that NEI neurons are responsive to the feedback mechanisms of the Hypothalamic Pituitary-Thyroid Axis (HPT). In conclusion, the hypothyroid status seems to increase the interactions between the NEI neurons and the dopaminergic pathways while hyperthyroidism either decreases or displays no effects. Altogether these observations support the participation of the IHy and PLH NEI as a modulating component of the HPT suggesting that altered neuroendocrine, behavioral and cognitive dysfunctions induced by dysthyroidism could be in part mediated by NEI.
Palabras clave: HYPERTHYROID STATUS , HYPOTHALAMUS , HYPOTHYROID STATUS , NEUROPEPTIDE (N) GLUTAMIC ACID (E) ISOLEUCINE (I) AMIDE (NEI) , PEDUNCULAR PART OF THE LATERAL HYPOTHALAMUS (PLH) , ROSTRAL/CAUDAL INCERTO-HYPOTHALAMIC AREA (IHY) , TYROSINE HYDROXYLASE (TH)
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Atribución-NoComercial-SinDerivadas 2.5 Argentina (CC BY-NC-ND 2.5 AR)
Identificadores
URI: http://hdl.handle.net/11336/88647
DOI: https://doi.org/10.1016/j.peptides.2018.12.008
URL: https://www.sciencedirect.com/science/article/pii/S0196978118302584
Colecciones
Articulos(IHEM)
Articulos de INST. HISTOLOGIA Y EMBRIOLOGIA DE MEND DR.M.BURGOS
Articulos(IMBECU)
Articulos de INST. DE MEDICINA Y BIO. EXP. DE CUYO
Citación
Ayala, Carolina; Pennacchio, Gisela Erika; Soaje, Marta; Bittencourt Guimaraes, Ana Tereza; Celis, Marìa E.; et al.; Differential effects of hypo- and hyperthyroidism on remodeling of contacts between neurons expressing the neuropeptide EI and tyrosine hydroxylase in hypothalamic areas of the male rat; Elsevier Science Inc; Peptides; 113; 3-2019; 1-10
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