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dc.contributor.author
Pedret, Anna
dc.contributor.author
Fernández Castillejo, Sara
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Valls, Rosa Maria
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Catalán, Úrsula
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Rubió, Laura
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Romeu, Marta
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Macià, Alba
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López de las Hazas, Maria Carmen
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Farràs, Marta
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Giralt, Montse
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Mosse, Juana Inés
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Martín Peláez, Sandra
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Remaley, Alan T.
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Covas, Maria Isabel
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Fitó, Montse
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Motilva, Maria José
dc.contributor.author
Solà, Rosa
dc.date.available
2019-11-08T15:15:14Z
dc.date.issued
2018-08
dc.identifier.citation
Pedret, Anna; Fernández Castillejo, Sara; Valls, Rosa Maria; Catalán, Úrsula; Rubió, Laura; et al.; Cardiovascular Benefits of Phenol-Enriched Virgin Olive Oils: New Insights from the Virgin Olive Oil and HDL Functionality (VOHF) Study; Wiley VCH Verlag; Molecular Nutrition & Food Research; 62; 16; 8-2018; 1-23
dc.identifier.issn
1613-4125
dc.identifier.uri
http://hdl.handle.net/11336/88331
dc.description.abstract
Scope: The main findings of the “Virgin Olive Oil and HDL Functionality” (VOHF) study and other related studies on the effect of phenol-enriched virgin olive oil (VOO) supplementation on cardiovascular disease are integrated in the present work. Methods and results: VOHF assessed whether VOOs, enriched with their own phenolic compounds (FVOO) or with those from thyme (FVOOT), improve quantity and functionality of HDL. In this randomized, double-blind, crossover, and controlled trial, 33 hypercholesterolemic subjects received a control VOO (80 mg kg−1), FVOO (500 mg kg−1), and FVOOT (500 mg kg−1; 1:1) for 3 weeks. Both functional VOOs promoted cardioprotective changes, modulating HDL proteome, increasing fat-soluble antioxidants, improving HDL subclasses distribution, reducing the lipoprotein insulin resistance index, increasing endogenous antioxidant enzymes, protecting DNA from oxidation, ameliorating endothelial function, and increasing fecal microbial metabolic activity. Additional cardioprotective benefits were observed according to phenol source and content in the phenol-enriched VOOs. These insights support the beneficial effects of OO and PC from different sources. Conclusion: Novel therapeutic strategies should increase HDL-cholesterol levels and enhance HDL functionality. The tailoring of phenol-enriched VOOs is an interesting and useful strategy for enhancing the functional quality of HDL, and thus, it can be used as a complementary tool for the management of hypercholesterolemic individuals.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley VCH Verlag
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
CARDIOVASCULAR
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HDL FUNCTIONALITY
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PHENOLIC COMPOUNDS
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POLYPHENOLS
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VIRGIN OLIVE OIL
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Nutrición, Dietética
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Ciencias de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Cardiovascular Benefits of Phenol-Enriched Virgin Olive Oils: New Insights from the Virgin Olive Oil and HDL Functionality (VOHF) Study
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-10-23T20:56:39Z
dc.journal.volume
62
dc.journal.number
16
dc.journal.pagination
1-23
dc.journal.pais
Alemania
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dc.journal.ciudad
Weinheim
dc.description.fil
Fil: Pedret, Anna. Universitat Rovira I Virgili; España
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Fil: Fernández Castillejo, Sara. Universitat Rovira I Virgili; España
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Fil: Valls, Rosa Maria. Universitat Rovira I Virgili; España
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Fil: Catalán, Úrsula. Universitat Rovira I Virgili; España
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Fil: Rubió, Laura. Universitat de Lleida; España
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Fil: Romeu, Marta. Universitat Rovira I Virgili; España
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Fil: Macià, Alba. Universitat de Lleida; España
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Fil: López de las Hazas, Maria Carmen. Universitat de Lleida; España
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Fil: Farràs, Marta. Instituto de Investigaciones Biomedicas Sant Pau; España
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Fil: Giralt, Montse. Universitat Rovira I Virgili; España
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Fil: Mosse, Juana Inés. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina
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Fil: Martín Peláez, Sandra. Instituto de Salud Carlos Iii; España
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Fil: Remaley, Alan T.. National Institutes Of Health; Estados Unidos
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Fil: Covas, Maria Isabel. Instituto de Salud Carlos Iii; España
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Fil: Fitó, Montse. Instituto de Salud Carlos Iii; España
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Fil: Motilva, Maria José. Universitat de Lleida; España
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Fil: Solà, Rosa. Universitat Rovira I Virgili; España
dc.journal.title
Molecular Nutrition & Food Research
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/mnfr.201800456
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info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/mnfr.201800456
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