Artículo
Cardiovascular Benefits of Phenol-Enriched Virgin Olive Oils: New Insights from the Virgin Olive Oil and HDL Functionality (VOHF) Study
Pedret, Anna; Fernández Castillejo, Sara; Valls, Rosa Maria; Catalán, Úrsula; Rubió, Laura; Romeu, Marta; Macià, Alba; López de las Hazas, Maria Carmen; Farràs, Marta; Giralt, Montse; Mosse, Juana Inés
; Martín Peláez, Sandra; Remaley, Alan T.; Covas, Maria Isabel; Fitó, Montse; Motilva, Maria José; Solà, Rosa
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Fecha de publicación:
08/2018
Editorial:
Wiley VCH Verlag
Revista:
Molecular Nutrition & Food Research
ISSN:
1613-4125
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Scope: The main findings of the “Virgin Olive Oil and HDL Functionality” (VOHF) study and other related studies on the effect of phenol-enriched virgin olive oil (VOO) supplementation on cardiovascular disease are integrated in the present work. Methods and results: VOHF assessed whether VOOs, enriched with their own phenolic compounds (FVOO) or with those from thyme (FVOOT), improve quantity and functionality of HDL. In this randomized, double-blind, crossover, and controlled trial, 33 hypercholesterolemic subjects received a control VOO (80 mg kg−1), FVOO (500 mg kg−1), and FVOOT (500 mg kg−1; 1:1) for 3 weeks. Both functional VOOs promoted cardioprotective changes, modulating HDL proteome, increasing fat-soluble antioxidants, improving HDL subclasses distribution, reducing the lipoprotein insulin resistance index, increasing endogenous antioxidant enzymes, protecting DNA from oxidation, ameliorating endothelial function, and increasing fecal microbial metabolic activity. Additional cardioprotective benefits were observed according to phenol source and content in the phenol-enriched VOOs. These insights support the beneficial effects of OO and PC from different sources. Conclusion: Novel therapeutic strategies should increase HDL-cholesterol levels and enhance HDL functionality. The tailoring of phenol-enriched VOOs is an interesting and useful strategy for enhancing the functional quality of HDL, and thus, it can be used as a complementary tool for the management of hypercholesterolemic individuals.
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Articulos(IBIMOL)
Articulos de INSTITUTO DE BIOQUIMICA Y MEDICINA MOLECULAR
Articulos de INSTITUTO DE BIOQUIMICA Y MEDICINA MOLECULAR
Citación
Pedret, Anna; Fernández Castillejo, Sara; Valls, Rosa Maria; Catalán, Úrsula; Rubió, Laura; et al.; Cardiovascular Benefits of Phenol-Enriched Virgin Olive Oils: New Insights from the Virgin Olive Oil and HDL Functionality (VOHF) Study; Wiley VCH Verlag; Molecular Nutrition & Food Research; 62; 16; 8-2018; 1-23
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