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dc.contributor.author
Herrera, Maria Silvia
dc.contributor.author
González, Sara Josefina
dc.contributor.author
Minsky, Daniel Mauricio
dc.contributor.author
Kreiner, Andres Juan
dc.date.available
2019-11-07T19:45:38Z
dc.date.issued
2013-09
dc.identifier.citation
Herrera, Maria Silvia; González, Sara Josefina; Minsky, Daniel Mauricio; Kreiner, Andres Juan; Evaluation of performance of an accelerator-based BNCT facility for the treatment of different tumor targets; Elsevier; Physica Medica; 29; 5; 9-2013; 436-446
dc.identifier.issn
1120-1797
dc.identifier.uri
http://hdl.handle.net/11336/88235
dc.description.abstract
Purpose: Encouraging Boron Neutron Capture Therapy (BNCT) clinical results obtained in recent years have stimulated intense research to develop accelerator-based neutron sources to be installed in clinical facilities. In this work an assessment of an accelerator-based BNCT facility for the treatment of different tumor targets was performed, comparing the accelerator-derived results with reported reactor-based trials under similar conditions and subjected to the same clinical protocols. Materials and methods: A set of real image studies was used to cover clinical-like cases of brain and head-and-neck tumors. In addition, two clinical cases of malignant nodular melanoma treated at the RA-6 BNCT facility in Argentina were used to thoroughly compare the clinical dosimetry with the accelerator-derived results. Results: The minimum weighted dose delivered to the clinical target volume was higher than 30 Gy and 14 Gy for the brain tumor and head-and-neck cases, respectively, in agreement with those achieved in clinical applications. For the melanoma cases, the minimum tumor doses were equal or higher than those achieved with the RA-6 reactor for identical field orientation and protocol. The whole-body dose assessment showed that the maximum photon-equivalent doses for those normal organs close to the beam direction were below the upper limits considered in the protocols used in the present work. Conclusions: The obtained results indicate not only the good performance of the proposedbeam shaping assembly design associated to the facility but also the potential applicability of accelerator-based BNCT in the treatment of both superficial and deep-seated tumors.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ACCELERATOR-BASED NEUTRON SOURCE
dc.subject
TREATMENT PLANNING ASSESSMENT
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WHOLE-BODY DOSE ASSESSMENT
dc.subject.classification
Otras Ciencias Físicas
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Ciencias Físicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Evaluation of performance of an accelerator-based BNCT facility for the treatment of different tumor targets
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-10-21T13:35:18Z
dc.journal.volume
29
dc.journal.number
5
dc.journal.pagination
436-446
dc.journal.pais
Italia
dc.description.fil
Fil: Herrera, Maria Silvia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica; Argentina. Universidad Nacional de San Martín. Escuela de Ciencia y Tecnología; Argentina
dc.description.fil
Fil: González, Sara Josefina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica; Argentina
dc.description.fil
Fil: Minsky, Daniel Mauricio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica; Argentina. Universidad Nacional de San Martín. Escuela de Ciencia y Tecnología; Argentina
dc.description.fil
Fil: Kreiner, Andres Juan. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica; Argentina. Universidad Nacional de San Martín. Escuela de Ciencia y Tecnología; Argentina
dc.journal.title
Physica Medica
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.ejmp.2013.01.006
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1120179713000070
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