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dc.contributor.author
Medina, Jorge Horacio  
dc.contributor.author
Viola, Haydee Ana Maria  
dc.date.available
2019-11-05T20:44:12Z  
dc.date.issued
2018-10  
dc.identifier.citation
Medina, Jorge Horacio; Viola, Haydee Ana Maria; ERK1/2: A Key Cellular Component for the Formation, Retrieval, Reconsolidation and Persistence of Memory; Frontiers Media S.A.; Frontiers in Molecular Neuroscience; 11; 361; 10-2018; 1-8  
dc.identifier.issn
1662-5099  
dc.identifier.uri
http://hdl.handle.net/11336/88095  
dc.description.abstract
Extracellular regulated kinase 1/2 (ERK1/2) has been strongly implicated in several cellular processes. In the brain ERK1/2 activity has been primarily involved in long-term memory (LTM) formation and expression. Here, we review earlier evidence and describe recent developments of ERK1/2 signaling in memory processing focusing the attention on the role of ERK1/2 in memory retrieval and reconsolidation, and in the maintenance of the memory trace including mechanisms involving the protection of labile memories. In addition, relearning requires ERK1/2 activity in selected brain regions. Its involvement in distinct memory stages points at ERK1/2 as a core element in memory processing and as one likely target to treat memory impairments associated with neurological disorders.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Frontiers Media S.A.  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
DURABILITY  
dc.subject
ERK1/2  
dc.subject
EXTINCTION  
dc.subject
LONG-TERM MEMORY  
dc.subject
RECONSOLIDATION  
dc.subject
RETRIEVAL  
dc.subject.classification
Otras Ciencias de la Salud  
dc.subject.classification
Ciencias de la Salud  
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
ERK1/2: A Key Cellular Component for the Formation, Retrieval, Reconsolidation and Persistence of Memory  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2019-10-23T14:41:01Z  
dc.journal.volume
11  
dc.journal.number
361  
dc.journal.pagination
1-8  
dc.journal.pais
Suiza  
dc.journal.ciudad
Lausanne  
dc.description.fil
Fil: Medina, Jorge Horacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina  
dc.description.fil
Fil: Viola, Haydee Ana Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina  
dc.journal.title
Frontiers in Molecular Neuroscience  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3389/fnmol.2018.00361  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fnmol.2018.00361/full