Artículo
ERK1/2: A Key Cellular Component for the Formation, Retrieval, Reconsolidation and Persistence of Memory
Fecha de publicación:
10/2018
Editorial:
Frontiers Media S.A.
Revista:
Frontiers in Molecular Neuroscience
ISSN:
1662-5099
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Extracellular regulated kinase 1/2 (ERK1/2) has been strongly implicated in several cellular processes. In the brain ERK1/2 activity has been primarily involved in long-term memory (LTM) formation and expression. Here, we review earlier evidence and describe recent developments of ERK1/2 signaling in memory processing focusing the attention on the role of ERK1/2 in memory retrieval and reconsolidation, and in the maintenance of the memory trace including mechanisms involving the protection of labile memories. In addition, relearning requires ERK1/2 activity in selected brain regions. Its involvement in distinct memory stages points at ERK1/2 as a core element in memory processing and as one likely target to treat memory impairments associated with neurological disorders.
Palabras clave:
DURABILITY
,
ERK1/2
,
EXTINCTION
,
LONG-TERM MEMORY
,
RECONSOLIDATION
,
RETRIEVAL
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Articulos(IBCN)
Articulos de INST.DE BIOLO.CEL.Y NEURCS."PROF.E.DE ROBERTIS"
Articulos de INST.DE BIOLO.CEL.Y NEURCS."PROF.E.DE ROBERTIS"
Citación
Medina, Jorge Horacio; Viola, Haydee Ana Maria; ERK1/2: A Key Cellular Component for the Formation, Retrieval, Reconsolidation and Persistence of Memory; Frontiers Media S.A.; Frontiers in Molecular Neuroscience; 11; 361; 10-2018; 1-8
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