Artículo
Diet Enriched with Olive Oil Attenuates Placental Dysfunction in Rats with Gestational Diabetes Induced by Intrauterine Programming
Capobianco, Evangelina Lorena
; Gomez Ribot, Dalmiro Leonardo Antonio; Fornes, Daiana
; Powell, Theresa L.; Levieux, Cecilia; Jansson, Thomas; Jawerbaum, Alicia Sandra
Fecha de publicación:
10/2018
Editorial:
Wiley VCH Verlag
Revista:
Molecular Nutrition & Food Research
ISSN:
0955-2863
e-ISSN:
1613-4125
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Scope: Offspring from rats with mild diabetes develop gestational diabetes mellitus (GDM). We tested the hypothesis that an olive oil-supplemented diet attenuates placental oxidative stress/inflammation, activation of mTOR signaling, and inhibition of peroxisome proliferator-activated receptor γ (PPARγ) and fetal overgrowth in GDM offspring from mild diabetic rats. Methods and results: Female offspring from rats with mild diabetes (group that developed GDM) and controls were fed with either a standard diet or a 6% olive oil-supplemented diet during pregnancy. On day 21 of pregnancy, plasma glucose levels in mothers and fetuses were increased in the GDM group independently of the diet. Fetal overgrowth and activation of placental mTOR signaling were partially prevented in the olive oil-treated GDM group. Placental PPARγ protein expression was decreased in GDM rats, independently of the diet. However, increases in placental lipoperoxidation, connective tissue growth factor, and matrix metalloproteinase 2 levels were prevented by the olive oil-enriched diet. Conclusion: Diets enriched with olive oil attenuate placental dysfunction and fetal overgrowth in rats with GDM induced by intrauterine programming.
Palabras clave:
DIABETES IN PREGNANCY
,
FETAL PROGRAMMING
,
MTOR
,
PLACENTA
,
PPAR
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Identificadores
Colecciones
Articulos(CEFYBO)
Articulos de CENTRO DE ESTUDIOS FARMACOLOGICOS Y BOTANICOS
Articulos de CENTRO DE ESTUDIOS FARMACOLOGICOS Y BOTANICOS
Citación
Capobianco, Evangelina Lorena; Gomez Ribot, Dalmiro Leonardo Antonio; Fornes, Daiana; Powell, Theresa L.; Levieux, Cecilia; et al.; Diet Enriched with Olive Oil Attenuates Placental Dysfunction in Rats with Gestational Diabetes Induced by Intrauterine Programming; Wiley VCH Verlag; Molecular Nutrition & Food Research; 62; 19; 10-2018; 1-27
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