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dc.contributor.author
Dias, L.
dc.contributor.author
Peloso, E.F.
dc.contributor.author
Leme, A.F.P.
dc.contributor.author
Carnielli, C.M.
dc.contributor.author
Pereira, C.N.
dc.contributor.author
Werneck, C.C.
dc.contributor.author
Guerrero, Sergio Adrian
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dc.contributor.author
Gadelha, F.R.
dc.date.available
2019-10-19T14:12:06Z
dc.date.issued
2018-01
dc.identifier.citation
Dias, L.; Peloso, E.F.; Leme, A.F.P.; Carnielli, C.M.; Pereira, C.N.; et al.; Trypanosoma cruzi tryparedoxin II interacts with different peroxiredoxins under physiological andoxidative stress conditions.; Academic Press Inc Elsevier Science; Experimental Parasitology; 184; 1-2018; 1-10
dc.identifier.issn
0014-4894
dc.identifier.uri
http://hdl.handle.net/11336/86530
dc.description.abstract
Trypanosoma cruzi, the etiologic agent of Chagas disease, has to cope with reactive oxygen and nitrogen species during its life cycle in order to ensure its survival and infection. The parasite detoxifies these species through a series of pathways centered on trypanothione that depend on glutathione or low molecular mass dithiol proteins such as tryparedoxins. These proteins transfer reducing equivalents to peroxidases, including mitochondrial and cytosolic peroxiredoxins, TcMPx and TcCPx, respectively. In T. cruzi two tryparedoxins have been identified, TXNI and TXNII with different intracellular locations. TXNI is a cytosolic protein while TXNII due to a C-terminal hydrophobic tail is anchored in the outer membrane of the mitochondrion, endoplasmic reticulum and glycosomes. TXNs have been suggested to be involved in a majority of biological processes ranging from redox mechanisms to protein translation. Herein, a comparison of the TXNII interactomes under physiological and oxidative stress conditions was examined. Under physiological conditions, apart from the proteins with unknown biological process annotation, the majority of the identified proteins are related to cell redox homeostasis and biosynthetic processes, while under oxidative stress conditions, are involved in stress response, cell redox homeostasis, arginine biosynthesis and microtubule based process. Interestingly, although TXNII interacts with both peroxiredoxins under physiological conditions, upon oxidative stress, TcMPx interaction prevails. The relevance of the interactions is discussed opening a new perspective of TXNII functions.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Academic Press Inc Elsevier Science
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Trypanosoma
dc.subject
Tryparedoxin
dc.subject
Peroxiredoxin
dc.subject.classification
Bioquímica y Biología Molecular
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Trypanosoma cruzi tryparedoxin II interacts with different peroxiredoxins under physiological andoxidative stress conditions.
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-10-18T18:44:13Z
dc.journal.volume
184
dc.journal.pagination
1-10
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Dias, L.. Universidade Estadual de Campinas; Brasil
dc.description.fil
Fil: Peloso, E.F.. Universidade Estadual de Campinas; Brasil
dc.description.fil
Fil: Leme, A.F.P.. Associaçáo Brasileira de Informática;
dc.description.fil
Fil: Carnielli, C.M.. Associaçáo Brasileira de Informática;
dc.description.fil
Fil: Pereira, C.N.. Universidade Estadual de Campinas; Brasil
dc.description.fil
Fil: Werneck, C.C.. Universidade Estadual de Campinas; Brasil
dc.description.fil
Fil: Guerrero, Sergio Adrian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Agrobiotecnología del Litoral. Universidad Nacional del Litoral. Instituto de Agrobiotecnología del Litoral; Argentina
dc.description.fil
Fil: Gadelha, F.R.. Universidade Estadual de Campinas; Brasil
dc.journal.title
Experimental Parasitology
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.exppara.2017.10.015
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