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dc.contributor.author
Altamirano, Gabriela Anahí
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Delconte, Melisa
dc.contributor.author
Gomez, Ayelen Luciana
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Ingaramo, Paola Inés
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Bosquiazzo, Veronica Lis
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Luque, Enrique Hugo
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Muñoz de Toro, Monica Milagros
dc.contributor.author
Kass, Laura
dc.date.available
2019-10-18T20:18:05Z
dc.date.issued
2018-08
dc.identifier.citation
Altamirano, Gabriela Anahí; Delconte, Melisa; Gomez, Ayelen Luciana; Ingaramo, Paola Inés; Bosquiazzo, Veronica Lis; et al.; Postnatal exposure to a glyphosate-based herbicide modifies mammary gland growth and development in Wistar male rats; Pergamon-Elsevier Science Ltd; Food And Chemical Toxicology; 118; 8-2018; 111-118
dc.identifier.issn
0278-6915
dc.identifier.uri
http://hdl.handle.net/11336/86491
dc.description.abstract
Our aim was to evaluate whether postnatal exposure to a glyphosate-based herbicide (GBH) modifies mammary gland development in pre- and post-pubertal male rats. From postnatal day 1 (PND1) to PND7, male rats were injected subcutaneously every 48 h with either saline solution (vehicle) or 2 mg GBH/kg·bw. On PND21 and PND60, mammary gland and blood samples were collected. Estradiol (E2) and testosterone (T) serum levels, mammary gland histology, collagen fiber organization, mast cell infiltration, proliferation index, and estrogen (ESR1) and androgen receptor (AR) expression levels were evaluated. At PND21, GBH-exposed male rats exhibited greater development of the mammary gland with increased stromal collagen organization and terminal end buds (TEBs) compared to control rats. At PND60, the number of TEBs remained high and was accompanied by an increase in mast cell infiltration, proliferation and ESR1 expression in GBH-exposed male rats. In contrast, no effects were observed in E2 and T serum levels and AR expression in both days studied. Our results showed that a postnatal subacute treatment with GBH induces endocrine-disrupting effects in the male mammary gland in vivo, altering its normal development.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Pergamon-Elsevier Science Ltd
dc.rights
info:eu-repo/semantics/openAccess
dc.rights
Atribución-NoComercial-CompartirIgual 2.5 Argentina (CC BY-NC-SA 2.5 AR)
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ESTROGEN RECEPTOR
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GLYPHOSATE-BASED HERBICIDE
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MALE RATS
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MAMMARY GLAND
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MAST CELLS
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Bioquímica y Biología Molecular
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Postnatal exposure to a glyphosate-based herbicide modifies mammary gland growth and development in Wistar male rats
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-10-18T18:43:55Z
dc.journal.volume
118
dc.journal.pagination
111-118
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Altamirano, Gabriela Anahí. Universidad Nacional del Litoral; Argentina
dc.description.fil
Fil: Delconte, Melisa. Universidad Nacional del Litoral; Argentina
dc.description.fil
Fil: Gomez, Ayelen Luciana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Salud y Ambiente del Litoral. Universidad Nacional del Litoral. Instituto de Salud y Ambiente del Litoral; Argentina
dc.description.fil
Fil: Ingaramo, Paola Inés. Universidad Nacional del Litoral; Argentina
dc.description.fil
Fil: Bosquiazzo, Veronica Lis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Salud y Ambiente del Litoral. Universidad Nacional del Litoral. Instituto de Salud y Ambiente del Litoral; Argentina
dc.description.fil
Fil: Luque, Enrique Hugo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Salud y Ambiente del Litoral. Universidad Nacional del Litoral. Instituto de Salud y Ambiente del Litoral; Argentina
dc.description.fil
Fil: Muñoz de Toro, Monica Milagros. Universidad Nacional del Litoral; Argentina
dc.description.fil
Fil: Kass, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Salud y Ambiente del Litoral. Universidad Nacional del Litoral. Instituto de Salud y Ambiente del Litoral; Argentina
dc.journal.title
Food And Chemical Toxicology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://linkinghub.elsevier.com/retrieve/pii/S0278691518303004
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.fct.2018.05.011
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