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Artículo

Postnatal exposure to a glyphosate-based herbicide modifies mammary gland growth and development in Wistar male rats

Altamirano, Gabriela AnahíIcon ; Delconte, Melisa; Gomez, Ayelen LucianaIcon ; Ingaramo, Paola InésIcon ; Bosquiazzo, Veronica LisIcon ; Luque, Enrique HugoIcon ; Muñoz de Toro, Monica Milagros; Kass, LauraIcon
Fecha de publicación: 08/2018
Editorial: Pergamon-Elsevier Science Ltd
Revista: Food And Chemical Toxicology
ISSN: 0278-6915
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Bioquímica y Biología Molecular

Resumen

Our aim was to evaluate whether postnatal exposure to a glyphosate-based herbicide (GBH) modifies mammary gland development in pre- and post-pubertal male rats. From postnatal day 1 (PND1) to PND7, male rats were injected subcutaneously every 48 h with either saline solution (vehicle) or 2 mg GBH/kg·bw. On PND21 and PND60, mammary gland and blood samples were collected. Estradiol (E2) and testosterone (T) serum levels, mammary gland histology, collagen fiber organization, mast cell infiltration, proliferation index, and estrogen (ESR1) and androgen receptor (AR) expression levels were evaluated. At PND21, GBH-exposed male rats exhibited greater development of the mammary gland with increased stromal collagen organization and terminal end buds (TEBs) compared to control rats. At PND60, the number of TEBs remained high and was accompanied by an increase in mast cell infiltration, proliferation and ESR1 expression in GBH-exposed male rats. In contrast, no effects were observed in E2 and T serum levels and AR expression in both days studied. Our results showed that a postnatal subacute treatment with GBH induces endocrine-disrupting effects in the male mammary gland in vivo, altering its normal development.
Palabras clave: ESTROGEN RECEPTOR , GLYPHOSATE-BASED HERBICIDE , MALE RATS , MAMMARY GLAND , MAST CELLS
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/86491
URL: http://linkinghub.elsevier.com/retrieve/pii/S0278691518303004
DOI: http://dx.doi.org/10.1016/j.fct.2018.05.011
Colecciones
Articulos(ISAL)
Articulos de INSTITUTO DE SALUD Y AMBIENTE DEL LITORAL
Citación
Altamirano, Gabriela Anahí; Delconte, Melisa; Gomez, Ayelen Luciana; Ingaramo, Paola Inés; Bosquiazzo, Veronica Lis; et al.; Postnatal exposure to a glyphosate-based herbicide modifies mammary gland growth and development in Wistar male rats; Pergamon-Elsevier Science Ltd; Food And Chemical Toxicology; 118; 8-2018; 111-118
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