Artículo
Postnatal exposure to a glyphosate-based herbicide modifies mammary gland growth and development in Wistar male rats
Altamirano, Gabriela Anahí
; Delconte, Melisa; Gomez, Ayelen Luciana
; Ingaramo, Paola Inés
; Bosquiazzo, Veronica Lis
; Luque, Enrique Hugo
; Muñoz de Toro, Monica Milagros; Kass, Laura
Fecha de publicación:
08/2018
Editorial:
Pergamon-Elsevier Science Ltd
Revista:
Food And Chemical Toxicology
ISSN:
0278-6915
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Our aim was to evaluate whether postnatal exposure to a glyphosate-based herbicide (GBH) modifies mammary gland development in pre- and post-pubertal male rats. From postnatal day 1 (PND1) to PND7, male rats were injected subcutaneously every 48 h with either saline solution (vehicle) or 2 mg GBH/kg·bw. On PND21 and PND60, mammary gland and blood samples were collected. Estradiol (E2) and testosterone (T) serum levels, mammary gland histology, collagen fiber organization, mast cell infiltration, proliferation index, and estrogen (ESR1) and androgen receptor (AR) expression levels were evaluated. At PND21, GBH-exposed male rats exhibited greater development of the mammary gland with increased stromal collagen organization and terminal end buds (TEBs) compared to control rats. At PND60, the number of TEBs remained high and was accompanied by an increase in mast cell infiltration, proliferation and ESR1 expression in GBH-exposed male rats. In contrast, no effects were observed in E2 and T serum levels and AR expression in both days studied. Our results showed that a postnatal subacute treatment with GBH induces endocrine-disrupting effects in the male mammary gland in vivo, altering its normal development.
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(ISAL)
Articulos de INSTITUTO DE SALUD Y AMBIENTE DEL LITORAL
Articulos de INSTITUTO DE SALUD Y AMBIENTE DEL LITORAL
Citación
Altamirano, Gabriela Anahí; Delconte, Melisa; Gomez, Ayelen Luciana; Ingaramo, Paola Inés; Bosquiazzo, Veronica Lis; et al.; Postnatal exposure to a glyphosate-based herbicide modifies mammary gland growth and development in Wistar male rats; Pergamon-Elsevier Science Ltd; Food And Chemical Toxicology; 118; 8-2018; 111-118
Compartir
Altmétricas