Artículo
First synthesis of (-)-neplanocin C
Fecha de publicación:
06/2000
Editorial:
Pergamon-Elsevier Science Ltd
Revista:
Tetrahedron
ISSN:
0040-4020
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
(-)-Neplanocin C (4), a minor component of the neplanocin family of antibiotics and a lead drug for the design of several conformationally constrained nucleosides analogues, was enantioselectively synthesized starting from D-ribono-1,4-lactone via a convergent approach in twelve steps. The proton NMR spectrum of 4 was in agreement with the corresponding natural product. Calculated coupling constants obtained from ab initio molecular modeling studies and from previously published X-ray structure of neplanocin C also corresponded to the spectroscopic data.
Palabras clave:
CARBOHYDRATES
,
ENANTIOMERIC PURITY
,
NUCLEOSIDES
,
PURINES
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Identificadores
Colecciones
Articulos(UMYMFOR)
Articulos de UNID.MICROANAL.Y MET.FISICOS EN QUIM.ORG.(I)
Articulos de UNID.MICROANAL.Y MET.FISICOS EN QUIM.ORG.(I)
Citación
Comin, Maria Julieta; Rodriguez, Juan Bautista; First synthesis of (-)-neplanocin C; Pergamon-Elsevier Science Ltd; Tetrahedron; 56; 27; 6-2000; 4639-4649
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