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dc.contributor.author
Bouzat, Cecilia Beatriz
dc.contributor.author
Sine, Steven M.
dc.date.available
2019-10-03T19:30:49Z
dc.date.issued
2018-06
dc.identifier.citation
Bouzat, Cecilia Beatriz; Sine, Steven M.; Nicotinic acetylcholine receptors at the single-channel level; Wiley Blackwell Publishing, Inc; British Journal of Pharmacology; 175; 11; 6-2018; 1789-1804
dc.identifier.issn
0007-1188
dc.identifier.uri
http://hdl.handle.net/11336/85155
dc.description.abstract
Over the past four decades, the patch clamp technique and nicotinic ACh (nACh) receptors have established an enduring partnership. Like all good partnerships, each partner has proven significant in its own right, while their union has spurred innumerable advances in life science research. A member and prototype of the superfamily of pentameric ligand-gated ion channels, the nACh receptor is a chemo-electric transducer, binding ACh released from nerves and rapidly opening its channel to cation flow to elicit cellular excitation. A subject of a Nobel Prize in Physiology or Medicine, the patch clamp technique provides unprecedented resolution of currents through single ion channels in their native cellular environments. Here, focusing on muscle and α7 nACh receptors, we describe the extraordinary contribution of the patch clamp technique towards understanding how they activate in response to neurotransmitter, how subtle structural and mechanistic differences among nACh receptor subtypes translate into significant physiological differences, and how nACh receptors are being exploited as therapeutic drug targets.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley Blackwell Publishing, Inc
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
NICOTINIC RECEPTOR
dc.subject
PATCH CLAMP
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SYNAPSIS
dc.subject
ION CHANNELS
dc.subject.classification
Biofísica
dc.subject.classification
Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Nicotinic acetylcholine receptors at the single-channel level
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2019-10-02T19:18:29Z
dc.identifier.eissn
1476-5381
dc.journal.volume
175
dc.journal.number
11
dc.journal.pagination
1789-1804
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Bouzat, Cecilia Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
dc.description.fil
Fil: Sine, Steven M.. Mayo Clinic. College of Medicine; Argentina
dc.journal.title
British Journal of Pharmacology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/bph.13770
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.13770
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