Artículo
Nicotinic acetylcholine receptors at the single-channel level
Fecha de publicación:
06/2018
Editorial:
Wiley Blackwell Publishing, Inc
Revista:
British Journal of Pharmacology
ISSN:
0007-1188
e-ISSN:
1476-5381
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Over the past four decades, the patch clamp technique and nicotinic ACh (nACh) receptors have established an enduring partnership. Like all good partnerships, each partner has proven significant in its own right, while their union has spurred innumerable advances in life science research. A member and prototype of the superfamily of pentameric ligand-gated ion channels, the nACh receptor is a chemo-electric transducer, binding ACh released from nerves and rapidly opening its channel to cation flow to elicit cellular excitation. A subject of a Nobel Prize in Physiology or Medicine, the patch clamp technique provides unprecedented resolution of currents through single ion channels in their native cellular environments. Here, focusing on muscle and α7 nACh receptors, we describe the extraordinary contribution of the patch clamp technique towards understanding how they activate in response to neurotransmitter, how subtle structural and mechanistic differences among nACh receptor subtypes translate into significant physiological differences, and how nACh receptors are being exploited as therapeutic drug targets.
Palabras clave:
NICOTINIC RECEPTOR
,
PATCH CLAMP
,
SYNAPSIS
,
ION CHANNELS
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Articulos(INIBIBB)
Articulos de INST.DE INVEST.BIOQUIMICAS BAHIA BLANCA (I)
Articulos de INST.DE INVEST.BIOQUIMICAS BAHIA BLANCA (I)
Citación
Bouzat, Cecilia Beatriz; Sine, Steven M.; Nicotinic acetylcholine receptors at the single-channel level; Wiley Blackwell Publishing, Inc; British Journal of Pharmacology; 175; 11; 6-2018; 1789-1804
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