Artículo
Low protein intake magnifies detrimental effects of ovariectomy and vitamin D on bone
Marotte, Clarisa
; Gonzales Chaves, Macarena Maria Sol
; Pellegrini, Gretel Gisela
; Friedman, Silvia María; Lifshitz, Fima; Mandalunis, Patricia Mónica; Zeni, Susana Noemi
Fecha de publicación:
08/2013
Editorial:
Springer
Revista:
Calcified Tissue International
ISSN:
0171-967X
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Protein-induced changes in bone and calcium homeostasis could potentially be greater in the elderly and in women at risk for osteoporosis. We hypothesize that a low protein intake would magnify the negative changes in bone metabolism seen in vitamin D (vitD) insufficiency and/or estrogen deficiency. The present study was undertaken to better understand how a low protein diet along with vitD insufficiency could affect bone metabolism using a rodent ovariectomized (OVX) model. Rats (n = 60) underwent ovariectomy (OVX) or sham operation. The first 15 days after surgery, all rats were fed a standard rodent diet. Thereafter, rats (n = 10/group) were fed a low protein diet (LP; 2.5 %) or a control diet (NP; 12.5 %) with 100 IU% vitD (+D; cholecalciferol) or without vitD (-D) for 45 days. The groups were as follows: SHAM + NP + D (control); SHAM + LP + D; SHAM + LP - D; OVX + NP + D; OVX + LP + D; OVX + LP - D. Body weight (BW) of control and OVX + NP + D groups increased while those feeding the LP diet, independently of vitD feedings, decreased (p < 0.05). The OVX + LP - D group presented the lowest serum Ca, phosphorus and osteocalcin levels and the highest CTX levels (p < 0.05). At the end of the study, total skeleton bone mineral content, proximal tibia bone mineral density, bone volume and trabecular number levels decreased as follows: SHAM + NP + D (controls) > SHAM + LP + D > OVX + NP + D > SHAM + LP - D > OVX + LP + D > OVX + LP - D (p < 0.05). A low protein diet negatively affected bone mass and magnified the detrimental effects of vitD and/or estrogen deficiencies.
Palabras clave:
BISPHOSPHONATE
,
BONE
,
LOW PROTEIN INTAKE
,
RATS
,
VITAMIN D INSUFFICIENCY
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Articulos(INIGEM)
Articulos de INSTITUTO DE INMUNOLOGIA, GENETICA Y METABOLISMO
Articulos de INSTITUTO DE INMUNOLOGIA, GENETICA Y METABOLISMO
Citación
Marotte, Clarisa; Gonzales Chaves, Macarena Maria Sol; Pellegrini, Gretel Gisela; Friedman, Silvia María; Lifshitz, Fima; et al.; Low protein intake magnifies detrimental effects of ovariectomy and vitamin D on bone; Springer; Calcified Tissue International; 93; 2; 8-2013; 184-192
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