Artículo
L-Tenuazonic Acid, a New Inhibitor of Paenibacillus Larvae
Gallardo, Gabriela Laura; Penalba, Nora Liliana; Chacana, Pablo Anibal
; Terzolo, Horacio Raúl; Cabrera, Gabriela Myriam
Fecha de publicación:
12/2004
Editorial:
Springer
Revista:
World Journal of Microbiology
ISSN:
0959-3993
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
A search for bioactive compounds, inhibitors of Paenibacillus larvae, the causal agent of American foulbrood, a honeybees' disease, was carried on. Extracts of two fungal strains, Alternaria brassicicola and Alternaria raphani, isolated from pollen collected from beehives, exhibited a specific inhibitory activity against this bacterium. From these extracts and by means of chromatographic steps and bioassay-guided fractionation, three tetramic acids were isolated. The compounds were identified by spectroscopic methods and the absolute stereochemistry was chemically determined. L-Tenuazonic acid was shown to be responsible for the antibiotic activity. This compound showed a MIC of 32 μg/ml, comparable with that of oxytetracycline, an antibiotic currently used for the prevention of American foulbrood.
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Articulos(UMYMFOR)
Articulos de UNID.MICROANAL.Y MET.FISICOS EN QUIM.ORG.(I)
Articulos de UNID.MICROANAL.Y MET.FISICOS EN QUIM.ORG.(I)
Citación
Gallardo, Gabriela Laura; Penalba, Nora Liliana; Chacana, Pablo Anibal; Terzolo, Horacio Raúl; Cabrera, Gabriela Myriam; L-Tenuazonic Acid, a New Inhibitor of Paenibacillus Larvae; Springer; World Journal of Microbiology; 20; 6; 12-2004; 609-612
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